Treatment volume, dose prescription and delivery techniques for dose-intensification in Rectal Cancer: A national survey

Maria Antonietta Gambacorta, Giuditta Chiloiro, Alessio Giuseppe Morganti, Marco Lupattelli, Monica Di Tommaso, Consuelo Rosa, Lucrezia Gasparini, Rita Marina Niespolo, Mattia Falchetto Osti, Sabrina Montrone, Nicola Simoni, Caterina Boso, Francesca Facchin, Maria Assunta Deidda, Cristina Piva, Cesare Guida, Fernando Munoz, Giovanni Battista Ivaldi, Vania Marchetti, Paola FranzoneCorrado Spatola, Pierfrancesco Franco, Vittorio Donato

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background/Aim: The aim of the study was to investigate boost volume definition, doses, and delivery techniques for rectal cancer dose intensification. Patients and Methods: An online survey was made on 25 items (characteristics, simulation, imaging, volumes, doses, planning and treatment). Results: Thirty-eight radiation oncologists joined the study. Twenty-one delivered long-course radiotherapy with dose intensification. Boost volume was delineated on diagnostic magnetic resonance imaging (MRI) in 18 centres (85.7%), and computed tomography (CT) and/or positron emission tomography-CT in 9 (42.8%); 16 centres (76.2%) performed co-registration with CT-simulation. Boost dose was delivered on gross tumor volume in 10 centres (47.6%) and on clinical target volume in 11 (52.4%). The most common total dose was 54-55 Gy (71.4%), with moderate hypofractionation (85.7%). Intensity-modulated radiotherapy (IMRT) was used in all centres, with simultaneous integrated boost in 17 (80.8%) and image-guidance in 18 (85.7%). Conclusion: A high quality of treatment using dose escalation can be inferred by widespread multidisciplinary discussion, MRI-based treatment volume delineation, and radiation delivery relying on IMRT with accurate image-guided radiation therapy protocols.
Lingua originaleEnglish
pagine (da-a)1985-1995
Numero di pagine11
RivistaAnticancer Research
Volume41
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Dose intensification
  • Radiotherapy, Intensity-Modulated
  • Intensity modulated radiotherapy
  • Rectal cancer
  • Simultaneous integrated boost
  • Female
  • Humans
  • Italy
  • Lymphatic Metastasis
  • Magnetic Resonance Imaging
  • Male
  • Neoplasm Staging
  • Positron Emission Tomography Computed Tomography
  • Positron-Emission Tomography
  • Practice Patterns, Physicians'
  • Radiotherapy Dosage
  • Radiotherapy, Image-Guided
  • Rectal Neoplasms
  • Surveys and Questionnaires
  • Survival Analysis
  • Tumor Burden
  • Radiotherapy Planning, Computer-Assisted
  • Gross tumor volume

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