Treatment strategies for invasive aspergillosis in neutropenic patients: voriconazole or liposomal amphotericin-B?

Livio Pagano, Luana Fianchi, Morena Caira, Cg Valentini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

2 Citazioni (Scopus)

Abstract

The proportion of patients with cancers who develop invasive fungal infections has increased dramatically over the past few decades. Most of these infections are diagnosed in patients with hematological malignancies, mainly in patients with acute myeloid leukemia and those undergoing allogeneic hematopoietic stem cell transplantation. For years deoxycolate amphotericin B has been considered the drug of choice for the treatment of invasive aspergillosis, but it has been outclassed by its lipid formulations and new triazoles (i.e. voriconazole), that produced better response rates; nonetheless recovery from neutropenia remains the most important factor influencing outcome.
Lingua originaleEnglish
pagine (da-a)5-8
Numero di pagine4
RivistaJournal of Chemotherapy
Volume23
Stato di pubblicazionePubblicato - 2011

Keywords

  • Amphotericin B
  • Antifungal Agents
  • Aspergillosis
  • Humans
  • Neutropenia
  • Pyrimidines
  • Triazoles

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