Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A

Giuseppe Brisinda, Nicola Silvestrini, Giuseppe Bianco, Giorgio Maria

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)


Botulinum toxin A inhibits neuromuscular transmission. It has become a drug with many indications. The range of clinical applications has grown to encompass several neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum toxin A provides benefit in diseases of the gastrointestinal tract. Although toxin blocks cholinergic nerve endings in the autonomic nervous system, it has also been shown that it does not block non-adrenergic non-cholinergic responses mediated by nitric oxide. This has promoted further interest in using botulinum toxin A as a treatment for overactive smooth muscles and sphincters. The introduction of this therapy has made the treatment of several clinical conditions easier, in the outpatient setting, at a lower cost and without permanent complications. This review presents current data on the use of botulinum toxin A in the treatment of pathological conditions of the gastrointestinal tract.
Lingua originaleEnglish
pagine (da-a)1882-1916
Numero di pagine35
Stato di pubblicazionePubblicato - 2015


  • anal fissure
  • botulinum toxin


Entra nei temi di ricerca di 'Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A'. Insieme formano una fingerprint unica.

Cita questo