TY - JOUR
T1 - Transplantation in the onco-hematology field: focus on the manipulation of αβ and γδ T cells
AU - Daniele, Nicola
AU - Scerpa, Maria Cristina
AU - Caniglia, Maurizio
AU - Bernardo, Maria Ester
AU - Rossi, Cecilia
AU - Ciammetti, Chiara
AU - Palumbo, Giuseppe
AU - Locatelli, Franco
AU - Isacchi, Giancarlo
AU - Zinno, Francesco
PY - 2012
Y1 - 2012
N2 - gamma/delta T cells represent a subset of T cells expressing a T cell receptor (TCR) variant composed of gamma and delta chains. The gamma/delta TCR is expressed by 2-10% of all T cells in human peripheral blood, whereas the majority of T cells express alpha/beta TCRs. gamma/delta T cells display a range of innate effector functions including rapid secretion of chemokines and cytokines, as well as target cell lysis. Recent interest has focused on the function of gamma/delta T lymphocytes in allogeneic transplantation in the onco-hematology field. Several studies, in vitro and in vivo, suggest that gamma/delta T lymphocytes are potential beneficial effector cells in the context of hematopoietic stem cell transplantation (HSCT). In addition, in this review, we discuss the depletion of alpha/beta T lymphocytes in the graft for allogeneic transplantation. In fact, an efficient TCR alpha/beta cell depletion potentially reduces the risk of GvHD. Furthermore, TCR alpha/beta T cell depletion, especially with immunomagnetic negative selection, retains other potential beneficial effector cells in the graft, such as gamma/delta T cells, NK cells, and stem cells. These "facilitating" cells might facilitate engraftment, exert GvL effects, and reduce the risk for infections. (C) 2011 Elsevier GmbH. All rights reserved.
AB - gamma/delta T cells represent a subset of T cells expressing a T cell receptor (TCR) variant composed of gamma and delta chains. The gamma/delta TCR is expressed by 2-10% of all T cells in human peripheral blood, whereas the majority of T cells express alpha/beta TCRs. gamma/delta T cells display a range of innate effector functions including rapid secretion of chemokines and cytokines, as well as target cell lysis. Recent interest has focused on the function of gamma/delta T lymphocytes in allogeneic transplantation in the onco-hematology field. Several studies, in vitro and in vivo, suggest that gamma/delta T lymphocytes are potential beneficial effector cells in the context of hematopoietic stem cell transplantation (HSCT). In addition, in this review, we discuss the depletion of alpha/beta T lymphocytes in the graft for allogeneic transplantation. In fact, an efficient TCR alpha/beta cell depletion potentially reduces the risk of GvHD. Furthermore, TCR alpha/beta T cell depletion, especially with immunomagnetic negative selection, retains other potential beneficial effector cells in the graft, such as gamma/delta T cells, NK cells, and stem cells. These "facilitating" cells might facilitate engraftment, exert GvL effects, and reduce the risk for infections. (C) 2011 Elsevier GmbH. All rights reserved.
KW - Allogeneic transplantation
KW - T cell depletion
KW - alpha beta T cells
KW - gamma delta T cells
KW - Allogeneic transplantation
KW - T cell depletion
KW - alpha beta T cells
KW - gamma delta T cells
UR - http://hdl.handle.net/10807/245735
U2 - 10.1016/j.prp.2011.10.006
DO - 10.1016/j.prp.2011.10.006
M3 - Article
SN - 0344-0338
VL - 208
SP - 67
EP - 73
JO - Pathology Research and Practice
JF - Pathology Research and Practice
ER -