TY - JOUR
T1 - Transplantation activities and treatment strategies in paediatric stem cell transplantation centres: a report from the EBMT Working Party on Paediatric Diseases. European Group for Blood and Marrow Transplantation
AU - Locatelli, Franco
PY - 1998
Y1 - 1998
N2 - To determine the current approach to stem cell transplantation (SCT) in centres which treat predominantly paediatric patients, a questionnaire was sent to 67 centres known by the EBMT registry to perform SCT mainly in children. Fifty-five centres from 19 countries responded. Forty centres (75%) started their transplantation activities between 1980 and 1992. Median number of transplants/centre was 95 (range 8-400). Median number of transplants/centre/year was 18 (range 5-85), On average, there was one physician responsible for seven SCT/year while one nurse was involved for a median of 1.7 SCT/year, Median four rooms/centre (range 1-17) were available for paediatric SCT, The most common isolation facilities were rooms with high efficiency particulate air filtration (HEPA). Eighty-two percent (45/55) of the centres performed allogeneic as well as autologous SCT, while 5% (three centres) offered exclusively allogeneic SCT and 13% (seven centres) used only autologous stem cell rescue. Stem cell source for allogeneic SCT was bone marrow in 87%, peripheral blood (PB) in 10% and umbilical cord blood in 3%, Donors were HLA matched related in 57%, mismatched related in 13%, and matched unrelated in 30% of allogeneic SCT, PB was the most commonly used stem cell source for autologous SCT (48%), followed by BM (41%) and the two together (11%). Data analysis revealed substantial differences in protective care, stem cell processing and transplantation procedures within the centres, irrespective of the country, centre size and transplant type.
AB - To determine the current approach to stem cell transplantation (SCT) in centres which treat predominantly paediatric patients, a questionnaire was sent to 67 centres known by the EBMT registry to perform SCT mainly in children. Fifty-five centres from 19 countries responded. Forty centres (75%) started their transplantation activities between 1980 and 1992. Median number of transplants/centre was 95 (range 8-400). Median number of transplants/centre/year was 18 (range 5-85), On average, there was one physician responsible for seven SCT/year while one nurse was involved for a median of 1.7 SCT/year, Median four rooms/centre (range 1-17) were available for paediatric SCT, The most common isolation facilities were rooms with high efficiency particulate air filtration (HEPA). Eighty-two percent (45/55) of the centres performed allogeneic as well as autologous SCT, while 5% (three centres) offered exclusively allogeneic SCT and 13% (seven centres) used only autologous stem cell rescue. Stem cell source for allogeneic SCT was bone marrow in 87%, peripheral blood (PB) in 10% and umbilical cord blood in 3%, Donors were HLA matched related in 57%, mismatched related in 13%, and matched unrelated in 30% of allogeneic SCT, PB was the most commonly used stem cell source for autologous SCT (48%), followed by BM (41%) and the two together (11%). Data analysis revealed substantial differences in protective care, stem cell processing and transplantation procedures within the centres, irrespective of the country, centre size and transplant type.
KW - stem cell transplantation
KW - children
KW - isolation
KW - blood cell support
KW - staff
KW - bone marrow harvesting
KW - rooms
KW - stem cell transplantation
KW - children
KW - isolation
KW - blood cell support
KW - staff
KW - bone marrow harvesting
KW - rooms
UR - http://hdl.handle.net/10807/264756
U2 - 10.1038/sj.bmt.1701365
DO - 10.1038/sj.bmt.1701365
M3 - Article
SN - 0268-3369
VL - 22
SP - 431
EP - 437
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
ER -