Transplantation activities and treatment strategies in paediatric stem cell transplantation centres: a report from the EBMT Working Party on Paediatric Diseases. European Group for Blood and Marrow Transplantation

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

To determine the current approach to stem cell transplantation (SCT) in centres which treat predominantly paediatric patients, a questionnaire was sent to 67 centres known by the EBMT registry to perform SCT mainly in children. Fifty-five centres from 19 countries responded. Forty centres (75%) started their transplantation activities between 1980 and 1992. Median number of transplants/centre was 95 (range 8-400). Median number of transplants/centre/year was 18 (range 5-85), On average, there was one physician responsible for seven SCT/year while one nurse was involved for a median of 1.7 SCT/year, Median four rooms/centre (range 1-17) were available for paediatric SCT, The most common isolation facilities were rooms with high efficiency particulate air filtration (HEPA). Eighty-two percent (45/55) of the centres performed allogeneic as well as autologous SCT, while 5% (three centres) offered exclusively allogeneic SCT and 13% (seven centres) used only autologous stem cell rescue. Stem cell source for allogeneic SCT was bone marrow in 87%, peripheral blood (PB) in 10% and umbilical cord blood in 3%, Donors were HLA matched related in 57%, mismatched related in 13%, and matched unrelated in 30% of allogeneic SCT, PB was the most commonly used stem cell source for autologous SCT (48%), followed by BM (41%) and the two together (11%). Data analysis revealed substantial differences in protective care, stem cell processing and transplantation procedures within the centres, irrespective of the country, centre size and transplant type.
Lingua originaleEnglish
pagine (da-a)431-437
Numero di pagine7
RivistaBone Marrow Transplantation
Volume22
DOI
Stato di pubblicazionePubblicato - 1998

Keywords

  • stem cell transplantation
  • children
  • isolation
  • blood cell support
  • staff
  • bone marrow harvesting
  • rooms

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