Transient state kinetic investigation of ferritin iron release

Gabriele Ciasca, Massimiliano Papi, Michela Chiarpotto, Cristina Rossi, Pasquale De Sole, M Rodio, G Campi, A. Bianconi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Increased iron concentration in tissues appears to be a factor in the genesis and development of inflammatory and degenerative diseases. By means of real-time small angle x-ray scatteringmeasurements, we studied the kinetics of iron release from the ferritin inorganic core as a function of time and distance from the iron core centre. Accordingly, the iron release process follows a three step model: (i) a defect nucleation in the outer part of the mineral core, (ii) the diffusion of the reducing agent towards the inner part of the core, and (iii) the erosion of the core from the inner to the outer part.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine3
RivistaApplied Physics Letters
Volume100
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Ferritin

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