Transferrin and infertility. Genetic-clinical investigations [TRANSFERRINA ED INFERTILITA: INDAGINE GENETICO-CLINICA. NOTA PRELIMINARE]

The role of transferrin in blastocyte implantation and the maintenance of the foetus in the uterus has been investigated by may researchers with the aim of identifying a correlation between genetic polymorphorism genotypes and fertility changes. It was decided to investigate the significant effect on the local population of the Tf(c2) variant. Beckman has suggested that this variant may be connected with a history of abortion. The transferrin genotypes of two groups of women were therefore identified: Group I with a history of early sporadic abortion, Group II with a history of 2 or more early spontaneous abortions. The results of the investigation carried out in Arezszo when then compared with the genotypic distribution of transferrin throughout the same province. The outcome shows the existence of an insignificant correlation with each genotype. These findings do not agree with Beckman's conclusions. The range of subjects studied will be extended and the research will also be carried out in other provinces with the aim of identifying different significant factors in view of the importance of this subject in the field of the aetiopathogenesis of infertility. |