Transcranial stimulation in frontotemporal dementia: a randomized, double-blind, sham-controlled trial

Maria Cotelli, Alberto Benussi, Valentina Dell’Era, Maura Cosseddu, Valentina Cantoni, Maria Sofia Cotelli, Rosa Manenti, Luisa Benussi, Chiara Brattini, Antonella Alberici, Barbara Borroni

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

5 Citazioni (Scopus)

Abstract

Introduction: Frontotemporal dementia (FTD) is a progressive disease for which no curative treatment is currently available. We aimed to determine whether transcranial direct current stimulation (tDCS) can modulate intracortical connectivity and improve cognition in symptomatic FTD patients and presymptomatic FTD subjects. Methods: We performed a double-blind, randomized, sham-controlled trial with anodal tDCS or sham stimulation over the left prefrontal cortex in 70 participants (15 presymptomatic and 55 symptomatic FTD). Results: We observed a significant increase of intracortical connectivity (short interval intracortical inhibition and facilitation) and improvement in clinical scores and behavioral disturbances in both symptomatic FTD patients and presymptomatic carriers after real tDCS but not after sham stimulation. Discussion: A 2-weeks’ treatment with anodal left prefrontal tDCS improves symptoms and restores intracortical inhibitory and excitatory circuits in both symptomatic FTD patients and presymptomatic carriers. tDCS might represent a promising future therapeutic and rehabilitative approach in patients with FTD.
Lingua originaleEnglish
pagine (da-a)1-11
Numero di pagine11
RivistaALZHEIMER'S & DEMENTIA. TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
Volume6
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Clinical trial
  • Frontotemporal dementia
  • Granulin
  • Transcranial magnetic stimulation
  • Short interval intracortical inhibition
  • Transcranial direct current stimulation
  • Presymptomatic

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