Abstract
Purpose: The purpose of this study was to evaluate feasibility, safety, tolerance, and efficacy of drug-eluting beads loaded with irinotecan (DEBIRI) in combination with capecitabine in the treatment of mCRC refractory to chemotherapy in patients affected by liver predominant metastatic disease. Materials and Methods: Twenty patients affected by CRC hepatic metastasis with liver-dominant disease, who had progression after two or more lines of chemotherapy, were enrolled. TACE with 100 mg of Irinotecan loaded into 2-ml of 70–150 µm drug-eluting beads was administrated every 4 weeks in patients with unilobar disease (2 treatments) and every 2 weeks in patients with bilobar disease (4 treatments). All patients assumed capecitabine 1000 mg/m2 twice daily on days 1–14 every 3 weeks, until disease progression. Primary endpoints were safety, tolerance and overall disease control (ODC); secondary endpoints were progression free survival (PFS) and overall survival (OS). Results: A total of 54 treatments were performed (54/66, 82 %). No intra/peri-procedural death occurred. During the mean follow-up of 11 months, two partial responses (PR) were reported with ODC of 60 % (2 PR + 10 stable disease). PFS and OS were 4 and 7.3 months, respectively. Univariate analysis showed that patients presenting with KRAS wild-type, good ECOG performance status and unilobar disease had a better prognosis. Only performance status (ECOG) correlated with OS in multivariate analysis (p = 0.03). Conclusion: DEBIRI with capecitabine seem to be a safe, technically feasible and well-tolerated treatment in chemotherapy refractory liver prevalent colorectal metastases.
Lingua originale | English |
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pagine (da-a) | 1523-1531 |
Numero di pagine | 9 |
Rivista | CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY |
Volume | 38 |
DOI | |
Stato di pubblicazione | Pubblicato - 2015 |
Keywords
- Aged
- Antimetabolites, Antineoplastic
- Antineoplastic Agents, Phytogenic
- Camptothecin
- Capecitabine
- Cardiology and Cardiovascular Medicine
- Chemoembolization
- Chemoembolization, Therapeutic
- Colorectal Neoplasms
- Disease-Free Survival
- Drug Delivery Systems
- Feasibility Studies
- Female
- Hepatic
- Humans
- Interventional Oncology
- Irinotecan
- Liver
- Liver Neoplasms
- Male
- Middle Aged
- Neoplasm
- Prospective Studies
- Radiology, Nuclear Medicine and Imaging
- Treatment Outcome
- Tumor