Toward noninvasive brain stimulation 2.0 in Alzheimer's disease

Maria Cotelli, Arianna Menardi, Simone Rossi, Giacomo Koch, Harald Hampel, Andrea Vergallo, Michael A. Nitsche, Yaakov Stern, Barbara Borroni, Stefano F. Cappa, Giulio Ruffini, Georges El-Fakhri, Brad Dickerson, Andrea Antal, Jean-Pascal Lefaucheur, Bruno Dubois, Gustavo Deco, Ulf Ziemann, Alvaro Pascual-Leone, Emiliano Santarnecchi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review


Noninvasive brain stimulation techniques (NiBS) have gathered substantial interest in the study of dementia, considered their possible role in help defining diagnostic biomarkers of altered neural activity for early disease detection and monitoring of its pathophysiological course, as well as for their therapeutic potential of boosting residual cognitive functions. Nevertheless, current approaches suffer from some limitations. In this study, we review and discuss experimental NiBS applications that might help improve the efficacy of future NiBS uses in Alzheimer's Disease (AD), including perturbation-based biomarkers for early diagnosis and disease tracking, solutions to enhance synchronization of oscillatory electroencephalographic activity across brain networks, enhancement of sleep-related memory consolidation, image-guided stimulation for connectome control, protocols targeting interneuron pathology and protein clearance, and finally hybrid-brain models for in-silico modeling of AD pathology and personalized target selection. The present work aims to stress the importance of multidisciplinary, translational, model-driven interventions for precision medicine approaches in AD.
Lingua originaleEnglish
pagine (da-a)1-17
Numero di pagine17
RivistaAgeing Research Reviews
Stato di pubblicazionePubblicato - 2022
Pubblicato esternamente


  • Alzheimer's disease
  • Noninvasive brain stimulation
  • Transcranial magnetic stimulation
  • Transcranial electrical stimulation
  • Precision medicine


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