TY - JOUR
T1 - Toward noninvasive brain stimulation 2.0 in Alzheimer's disease
AU - Menardi, Arianna
AU - Rossi, Simone
AU - Koch, Giacomo
AU - Hampel, Harald
AU - Vergallo, Andrea
AU - Nitsche, Michael A.
AU - Stern, Yaakov
AU - Borroni, Barbara
AU - Cappa, Stefano F.
AU - Cotelli, Maria
AU - Ruffini, Giulio
AU - El-Fakhri, Georges
AU - Rossini, Paolo M.
AU - Dickerson, Brad
AU - Antal, Andrea
AU - Babiloni, Claudio
AU - Lefaucheur, Jean-Pascal
AU - Dubois, Bruno
AU - Deco, Gustavo
AU - Ziemann, Ulf
AU - Pascual-Leone, Alvaro
AU - Santarnecchi, Emiliano
PY - 2022
Y1 - 2022
N2 - Noninvasive brain stimulation techniques (NiBS) have gathered substantial interest in the study of dementia, considered their possible role in help defining diagnostic biomarkers of altered neural activity for early disease detection and monitoring of its pathophysiological course, as well as for their therapeutic potential of boosting residual cognitive functions. Nevertheless, current approaches suffer from some limitations. In this study, we review and discuss experimental NiBS applications that might help improve the efficacy of future NiBS uses in Alzheimer's Disease (AD), including perturbation-based biomarkers for early diagnosis and disease tracking, solutions to enhance synchronization of oscillatory electroencephalographic activity across brain networks, enhancement of sleep-related memory consolidation, image-guided stimulation for connectome control, protocols targeting interneuron pathology and protein clearance, and finally hybrid-brain models for in-silico modeling of AD pathology and personalized target selection. The present work aims to stress the importance of multidisciplinary, translational, model-driven interventions for precision medicine approaches in AD.
AB - Noninvasive brain stimulation techniques (NiBS) have gathered substantial interest in the study of dementia, considered their possible role in help defining diagnostic biomarkers of altered neural activity for early disease detection and monitoring of its pathophysiological course, as well as for their therapeutic potential of boosting residual cognitive functions. Nevertheless, current approaches suffer from some limitations. In this study, we review and discuss experimental NiBS applications that might help improve the efficacy of future NiBS uses in Alzheimer's Disease (AD), including perturbation-based biomarkers for early diagnosis and disease tracking, solutions to enhance synchronization of oscillatory electroencephalographic activity across brain networks, enhancement of sleep-related memory consolidation, image-guided stimulation for connectome control, protocols targeting interneuron pathology and protein clearance, and finally hybrid-brain models for in-silico modeling of AD pathology and personalized target selection. The present work aims to stress the importance of multidisciplinary, translational, model-driven interventions for precision medicine approaches in AD.
KW - Alzheimer's disease
KW - Noninvasive brain stimulation
KW - Precision medicine
KW - Transcranial electrical stimulation
KW - Transcranial magnetic stimulation
KW - Alzheimer's disease
KW - Noninvasive brain stimulation
KW - Precision medicine
KW - Transcranial electrical stimulation
KW - Transcranial magnetic stimulation
UR - http://hdl.handle.net/10807/202700
U2 - 10.1016/j.arr.2021.101555
DO - 10.1016/j.arr.2021.101555
M3 - Article
SN - 1568-1637
VL - 75
SP - 1
EP - 17
JO - Ageing Research Reviews
JF - Ageing Research Reviews
ER -