Top-down analytical platforms for the characterization of the human salivary proteome.

Massimo Castagnola, Tiziana Cabras, Barbara Manconi, Alessandra Olianas, Maria Teresa Sanna, Irene Messana

Risultato della ricerca: Contributo in rivistaArticolo in rivista

23 Citazioni (Scopus)

Abstract

Comprehensive analysis and characterization of the human salivary proteome is an important step towards the possible use of saliva for diagnostic and prognostic purposes. The contribution of the different sources to whole saliva, and the evaluation of individual variability and physiological modifications have been investigated by top-down proteomic approaches, disclosing the faceted and complex profile of the human salivary proteome. All this information is essential to develop saliva protein biomarkers. In this Review the major results obtained in the field by top-down platforms, and the improvements required to allow a more complete picture, will be discussed.
Lingua originaleEnglish
pagine (da-a)563-581
Numero di pagine19
RivistaBioanalysis
Stato di pubblicazionePubblicato - 2014

Keywords

  • Analytical
  • Proteome

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