Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis

R Menghini; U Campia; M Tesauro; A Marino; V Rovella; G Rodia; F Schinzari; Barbara Tolusso; N Di Daniele; M Federici; Angelo Zoli; Gianfranco Ferraccioli; Carmine Cardillo

doi:10.1371/journal.pone.0099053

Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis

R Menghini
, U Campia
, M Tesauro
, A Marino
, V Rovella
, G Rodia
, F Schinzari
, Barbara Tolusso
, N Di Daniele
, M Federici
, Angelo Zoli
, Gianfranco Ferraccioli
, Carmine Cardillo

Risultato della ricerca: Contributo in rivista › Articolo

27 Citazioni (Scopus)

Abstract

To investigate the effects of TLR4 antagonism on human endothelial cells activation and cytokine expression, and whether the Asp299Gly TLR4 polymorphism is associated with better endothelial function in patients with rheumatoid arthritis (RA).

Lingua originale	Inglese
pagine (da-a)	e99053-e99053
Rivista	PLoS One
Volume	9
Numero di pubblicazione	6
DOI	https://doi.org/10.1371/journal.pone.0099053
Stato di pubblicazione	Pubblicato - 2014

Keywords

Aorta
Arthritis
Cells
Cultured
Disaccharides
Endothelium
Humans
Lipopolysaccharides
NF-kappa B
Phosphorylation
Rheumatoid
Sugar Phosphates
Toll-Like Receptor 4
Vascular

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10.1371/journal.pone.0099053

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Menghini, R., Campia, U., Tesauro, M., Marino, A., Rovella, V., Rodia, G., Schinzari, F., Tolusso, B., Di Daniele, N., Federici, M., Zoli, A., Ferraccioli, G., & Cardillo, C. (2014). Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis. PLoS One, 9(6), e99053-e99053. https://doi.org/10.1371/journal.pone.0099053

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title = "Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis",

abstract = "To investigate the effects of TLR4 antagonism on human endothelial cells activation and cytokine expression, and whether the Asp299Gly TLR4 polymorphism is associated with better endothelial function in patients with rheumatoid arthritis (RA).",

keywords = "Aorta, Arthritis, Cells, Cultured, Disaccharides, Endothelium, Humans, Lipopolysaccharides, NF-kappa B, Phosphorylation, Rheumatoid, Sugar Phosphates, Toll-Like Receptor 4, Vascular, Aorta, Arthritis, Cells, Cultured, Disaccharides, Endothelium, Humans, Lipopolysaccharides, NF-kappa B, Phosphorylation, Rheumatoid, Sugar Phosphates, Toll-Like Receptor 4, Vascular",

author = "R Menghini and U Campia and M Tesauro and A Marino and V Rovella and G Rodia and F Schinzari and Barbara Tolusso and \{Di Daniele\}, N and M Federici and Angelo Zoli and Gianfranco Ferraccioli and Carmine Cardillo",

year = "2014",

doi = "10.1371/journal.pone.0099053",

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Menghini, R, Campia, U, Tesauro, M, Marino, A, Rovella, V, Rodia, G, Schinzari, F, Tolusso, B, Di Daniele, N, Federici, M, Zoli, A, Ferraccioli, G & Cardillo, C 2014, 'Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis', PLoS One, vol. 9, n. 6, pagg. e99053-e99053. https://doi.org/10.1371/journal.pone.0099053

TY - JOUR

T1 - Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis

AU - Menghini, R

AU - Campia, U

AU - Tesauro, M

AU - Marino, A

AU - Rovella, V

AU - Rodia, G

AU - Schinzari, F

AU - Tolusso, Barbara

AU - Di Daniele, N

AU - Federici, M

AU - Zoli, Angelo

AU - Ferraccioli, Gianfranco

AU - Cardillo, Carmine

PY - 2014

Y1 - 2014

N2 - To investigate the effects of TLR4 antagonism on human endothelial cells activation and cytokine expression, and whether the Asp299Gly TLR4 polymorphism is associated with better endothelial function in patients with rheumatoid arthritis (RA).

AB - To investigate the effects of TLR4 antagonism on human endothelial cells activation and cytokine expression, and whether the Asp299Gly TLR4 polymorphism is associated with better endothelial function in patients with rheumatoid arthritis (RA).

KW - Aorta

KW - Arthritis

KW - Cells

KW - Cultured

KW - Disaccharides

KW - Endothelium

KW - Humans

KW - Lipopolysaccharides

KW - NF-kappa B

KW - Phosphorylation

KW - Rheumatoid

KW - Sugar Phosphates

KW - Toll-Like Receptor 4

KW - Vascular

KW - Aorta

KW - Arthritis

KW - Cells

KW - Cultured

KW - Disaccharides

KW - Endothelium

KW - Humans

KW - Lipopolysaccharides

KW - NF-kappa B

KW - Phosphorylation

KW - Rheumatoid

KW - Sugar Phosphates

KW - Toll-Like Receptor 4

KW - Vascular

UR - https://publicatt.unicatt.it/handle/10807/64922

U2 - 10.1371/journal.pone.0099053

DO - 10.1371/journal.pone.0099053

M3 - Article

SN - 1932-6203

VL - 9

SP - e99053-e99053

JO - PLoS One

JF - PLoS One

IS - 6

ER -

Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis

Abstract

Keywords

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