TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes

Angelo Santoliquido, Paolo Tondi, Dario Pitocco, Antonio Gasbarrini, Andrea Flex, Federico Biscetti, Flavio Bertucci, Giuseppe Straface, Flavia Angelini, Raffaele Landolfi, Luca Santoro

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

19 Citazioni (Scopus)

Abstract

Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.
Lingua originaleEnglish
pagine (da-a)1025-1032
Numero di pagine8
RivistaActa Diabetologica
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Atherosclerosis
  • Diabetes
  • Gene Polymorphism
  • Peripheral arterial disease

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