Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study

Amelia Evoli; Stefano Sioletic; Libero Lauriola; Pierluigi Granone; Rossano Lattanzio; Rossana La Sorda; Francesco Facciolo; Robert Martucci; Enzo Gallo; Giovannella Palmieri; Gabriele Alessandrini; Luigi Ruco; Erino Angelo Rendina; Mauro Truini; Roberto Chiarle; Antonella Barreca; Achille Pich; Stefano Ascani; Daniele Remotti; Gianni Tunesi; Giovanni Battista Ratto; Francesco Puma; Edoardo Pescarmona; Mauro Piantelli; Mirella Marino; Sandro Carlini; Virna Cerasoli; Felicita Corzani; Enrico Melis; Massimo Filippetti; Paola Canalini; Giorgio Palestro; Maurizio Lalle; Enrico Ruffini; Anna Ceribelli; Massimo Rinaldi

doi:10.1016/j.lungcan.2014.05.010

Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study

Amelia Evoli, Stefano Sioletic, Libero Lauriola, Pierluigi Granone, Rossano Lattanzio, Rossana La Sorda, Francesco Facciolo, Robert Martucci, Enzo Gallo, Giovannella Palmieri, Gabriele Alessandrini, Luigi Ruco, Erino Angelo Rendina, Mauro Truini, Roberto Chiarle, Antonella Barreca, Achille Pich, Stefano Ascani, Daniele Remotti, Gianni TunesiGiovanni Battista Ratto, Francesco Puma, Edoardo Pescarmona, Mauro Piantelli, Mirella Marino, Sandro Carlini, Virna Cerasoli, Felicita Corzani, Enrico Melis, Massimo Filippetti, Paola Canalini, Giorgio Palestro, Maurizio Lalle, Enrico Ruffini, Anna Ceribelli, Massimo Rinaldi

Risultato della ricerca: Contributo in rivista › Articolo in rivista

18 Citazioni (Scopus)

Abstract

Tumor angiogenesis is an essential and complex process necessary for the growth of all tumors which represents a potential therapeutic target. Angiogenesis inhibitors targeting vascular endothelial growth factor (VEGF) or their receptor tyrosine kinases have been approved by the FDA. In thymic epithelial tumors (TET), targeted therapies have been sporadically applied due to their rarity. To ascertain the presence of potential therapeutic targets, we analyzed by immunohistochemistry the expression of angiogenesis-related biomarkers in a large series of TET arranged in Tissue Micro Arrays (TMA).

Lingua originale	English
pagine (da-a)	191-196
Numero di pagine	6
Rivista	Lung Cancer
Volume	85
DOI	https://doi.org/10.1016/j.lungcan.2014.05.010
Stato di pubblicazione	Pubblicato - 2014

Keywords

Biomarkers
Thymic epithelial tumors
Thymoma
Tissue Micro Array
Vascular endothelial growth factor
Vascular endothelial growth factor receptor

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10.1016/j.lungcan.2014.05.010

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Evoli, A., Sioletic, S., Lauriola, L., Granone, P., Lattanzio, R., La Sorda, R., Facciolo, F., Martucci, R., Gallo, E., Palmieri, G., Alessandrini, G., Ruco, L., Rendina, E. A., Truini, M., Chiarle, R., Barreca, A., Pich, A., Ascani, S., Remotti, D., ... Rinaldi, M. (2014). Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study. Lung Cancer, 85, 191-196. https://doi.org/10.1016/j.lungcan.2014.05.010

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title = "Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study",

abstract = "Tumor angiogenesis is an essential and complex process necessary for the growth of all tumors which represents a potential therapeutic target. Angiogenesis inhibitors targeting vascular endothelial growth factor (VEGF) or their receptor tyrosine kinases have been approved by the FDA. In thymic epithelial tumors (TET), targeted therapies have been sporadically applied due to their rarity. To ascertain the presence of potential therapeutic targets, we analyzed by immunohistochemistry the expression of angiogenesis-related biomarkers in a large series of TET arranged in Tissue Micro Arrays (TMA).",

keywords = "Biomarkers, Thymic epithelial tumors, Thymoma, Tissue Micro Array, Vascular endothelial growth factor, Vascular endothelial growth factor receptor, Biomarkers, Thymic epithelial tumors, Thymoma, Tissue Micro Array, Vascular endothelial growth factor, Vascular endothelial growth factor receptor",

author = "Amelia Evoli and Stefano Sioletic and Libero Lauriola and Pierluigi Granone and Rossano Lattanzio and {La Sorda}, Rossana and Francesco Facciolo and Robert Martucci and Enzo Gallo and Giovannella Palmieri and Gabriele Alessandrini and Luigi Ruco and Rendina, {Erino Angelo} and Mauro Truini and Roberto Chiarle and Antonella Barreca and Achille Pich and Stefano Ascani and Daniele Remotti and Gianni Tunesi and Ratto, {Giovanni Battista} and Francesco Puma and Edoardo Pescarmona and Mauro Piantelli and Mirella Marino and Sandro Carlini and Virna Cerasoli and Felicita Corzani and Enrico Melis and Massimo Filippetti and Paola Canalini and Giorgio Palestro and Maurizio Lalle and Enrico Ruffini and Anna Ceribelli and Massimo Rinaldi",

year = "2014",

doi = "10.1016/j.lungcan.2014.05.010",

language = "English",

volume = "85",

pages = "191--196",

journal = "Lung Cancer",

issn = "0169-5002",

publisher = "Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114",

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Evoli, A, Sioletic, S, Lauriola, L, Granone, P, Lattanzio, R, La Sorda, R, Facciolo, F, Martucci, R, Gallo, E, Palmieri, G, Alessandrini, G, Ruco, L, Rendina, EA, Truini, M, Chiarle, R, Barreca, A, Pich, A, Ascani, S, Remotti, D, Tunesi, G, Ratto, GB, Puma, F, Pescarmona, E, Piantelli, M, Marino, M, Carlini, S, Cerasoli, V, Corzani, F, Melis, E, Filippetti, M, Canalini, P, Palestro, G, Lalle, M, Ruffini, E, Ceribelli, A & Rinaldi, M 2014, 'Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study', Lung Cancer, vol. 85, pagg. 191-196. https://doi.org/10.1016/j.lungcan.2014.05.010

TY - JOUR

T1 - Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study

AU - Evoli, Amelia

AU - Sioletic, Stefano

AU - Lauriola, Libero

AU - Granone, Pierluigi

AU - Lattanzio, Rossano

AU - La Sorda, Rossana

AU - Facciolo, Francesco

AU - Martucci, Robert

AU - Gallo, Enzo

AU - Palmieri, Giovannella

AU - Alessandrini, Gabriele

AU - Ruco, Luigi

AU - Rendina, Erino Angelo

AU - Truini, Mauro

AU - Chiarle, Roberto

AU - Barreca, Antonella

AU - Pich, Achille

AU - Ascani, Stefano

AU - Remotti, Daniele

AU - Tunesi, Gianni

AU - Ratto, Giovanni Battista

AU - Puma, Francesco

AU - Pescarmona, Edoardo

AU - Piantelli, Mauro

AU - Marino, Mirella

AU - Carlini, Sandro

AU - Cerasoli, Virna

AU - Corzani, Felicita

AU - Melis, Enrico

AU - Filippetti, Massimo

AU - Canalini, Paola

AU - Palestro, Giorgio

AU - Lalle, Maurizio

AU - Ruffini, Enrico

AU - Ceribelli, Anna

AU - Rinaldi, Massimo

PY - 2014

Y1 - 2014

N2 - Tumor angiogenesis is an essential and complex process necessary for the growth of all tumors which represents a potential therapeutic target. Angiogenesis inhibitors targeting vascular endothelial growth factor (VEGF) or their receptor tyrosine kinases have been approved by the FDA. In thymic epithelial tumors (TET), targeted therapies have been sporadically applied due to their rarity. To ascertain the presence of potential therapeutic targets, we analyzed by immunohistochemistry the expression of angiogenesis-related biomarkers in a large series of TET arranged in Tissue Micro Arrays (TMA).

AB - Tumor angiogenesis is an essential and complex process necessary for the growth of all tumors which represents a potential therapeutic target. Angiogenesis inhibitors targeting vascular endothelial growth factor (VEGF) or their receptor tyrosine kinases have been approved by the FDA. In thymic epithelial tumors (TET), targeted therapies have been sporadically applied due to their rarity. To ascertain the presence of potential therapeutic targets, we analyzed by immunohistochemistry the expression of angiogenesis-related biomarkers in a large series of TET arranged in Tissue Micro Arrays (TMA).

KW - Biomarkers

KW - Thymic epithelial tumors

KW - Thymoma

KW - Tissue Micro Array

KW - Vascular endothelial growth factor

KW - Vascular endothelial growth factor receptor

KW - Biomarkers

KW - Thymic epithelial tumors

KW - Thymoma

KW - Tissue Micro Array

KW - Vascular endothelial growth factor

KW - Vascular endothelial growth factor receptor

UR - http://hdl.handle.net/10807/62803

U2 - 10.1016/j.lungcan.2014.05.010

DO - 10.1016/j.lungcan.2014.05.010

M3 - Article

VL - 85

SP - 191

EP - 196

JO - Lung Cancer

JF - Lung Cancer

SN - 0169-5002

ER -

Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study

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Keywords

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