Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study

Amelia Evoli, Stefano Sioletic, Libero Lauriola, Pierluigi Granone, Rossano Lattanzio, Rossana La Sorda, Francesco Facciolo, Robert Martucci, Enzo Gallo, Giovannella Palmieri, Gabriele Alessandrini, Luigi Ruco, Erino Angelo Rendina, Mauro Truini, Roberto Chiarle, Antonella Barreca, Achille Pich, Stefano Ascani, Daniele Remotti, Gianni TunesiGiovanni Battista Ratto, Francesco Puma, Edoardo Pescarmona, Mauro Piantelli, Mirella Marino, Sandro Carlini, Virna Cerasoli, Felicita Corzani, Enrico Melis, Massimo Filippetti, Paola Canalini, Giorgio Palestro, Maurizio Lalle, Enrico Ruffini, Anna Ceribelli, Massimo Rinaldi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

Tumor angiogenesis is an essential and complex process necessary for the growth of all tumors which represents a potential therapeutic target. Angiogenesis inhibitors targeting vascular endothelial growth factor (VEGF) or their receptor tyrosine kinases have been approved by the FDA. In thymic epithelial tumors (TET), targeted therapies have been sporadically applied due to their rarity. To ascertain the presence of potential therapeutic targets, we analyzed by immunohistochemistry the expression of angiogenesis-related biomarkers in a large series of TET arranged in Tissue Micro Arrays (TMA).
Lingua originaleEnglish
pagine (da-a)191-196
Numero di pagine6
RivistaLung Cancer
Volume85
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Biomarkers
  • Thymic epithelial tumors
  • Thymoma
  • Tissue Micro Array
  • Vascular endothelial growth factor
  • Vascular endothelial growth factor receptor

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