Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease

A Ansari; Cesare Hassan; J Duley; A Marinaki; E Shobowale Bakre; P Seed; J Meenan; A Yim; J. Sanderson

Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease

A Ansari, Cesare Hassan, J Duley, A Marinaki, E Shobowale Bakre, P Seed, J Meenan, A Yim, J. Sanderson

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Azathioprine therapy is discontinued in one-third of patients with inflammatory bowel disease because of toxicity or a lack of clinical response. Patients with thiopurine methyltransferase (TPMT) deficiency are intolerant to azathioprine, whilst carriers are at increased risk of side-effects.

Lingua originale	English
pagine (da-a)	1743-1750
Numero di pagine	8
Rivista	ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Volume	16
Stato di pubblicazione	Pubblicato - 2002
Pubblicato esternamente	Sì

Keywords

Adult
Azathioprine
Biological Markers
Erythrocytes
Female
Genotype
Humans
Immunosuppressive Agents
Inflammatory Bowel Diseases
Leukocyte Count
Logistic Models
Male
Methyltransferases
Middle Aged
Odds Ratio
Retrospective Studies
Treatment Failure

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title = "Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease",

abstract = "Azathioprine therapy is discontinued in one-third of patients with inflammatory bowel disease because of toxicity or a lack of clinical response. Patients with thiopurine methyltransferase (TPMT) deficiency are intolerant to azathioprine, whilst carriers are at increased risk of side-effects.",

keywords = "Adult, Azathioprine, Biological Markers, Erythrocytes, Female, Genotype, Humans, Immunosuppressive Agents, Inflammatory Bowel Diseases, Leukocyte Count, Logistic Models, Male, Methyltransferases, Middle Aged, Odds Ratio, Retrospective Studies, Treatment Failure, Adult, Azathioprine, Biological Markers, Erythrocytes, Female, Genotype, Humans, Immunosuppressive Agents, Inflammatory Bowel Diseases, Leukocyte Count, Logistic Models, Male, Methyltransferases, Middle Aged, Odds Ratio, Retrospective Studies, Treatment Failure",

author = "A Ansari and Cesare Hassan and J Duley and A Marinaki and {Shobowale Bakre}, E and P Seed and J Meenan and A Yim and J. Sanderson",

year = "2002",

language = "English",

volume = "16",

pages = "1743--1750",

journal = "ALIMENTARY PHARMACOLOGY & THERAPEUTICS",

issn = "0269-2813",

publisher = "Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: [email protected], INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205",

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TY - JOUR

T1 - Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease

AU - Ansari, A

AU - Hassan, Cesare

AU - Duley, J

AU - Marinaki, A

AU - Shobowale Bakre, E

AU - Seed, P

AU - Meenan, J

AU - Yim, A

AU - Sanderson, J.

PY - 2002

Y1 - 2002

N2 - Azathioprine therapy is discontinued in one-third of patients with inflammatory bowel disease because of toxicity or a lack of clinical response. Patients with thiopurine methyltransferase (TPMT) deficiency are intolerant to azathioprine, whilst carriers are at increased risk of side-effects.

AB - Azathioprine therapy is discontinued in one-third of patients with inflammatory bowel disease because of toxicity or a lack of clinical response. Patients with thiopurine methyltransferase (TPMT) deficiency are intolerant to azathioprine, whilst carriers are at increased risk of side-effects.

KW - Adult

KW - Azathioprine

KW - Biological Markers

KW - Erythrocytes

KW - Female

KW - Genotype

KW - Humans

KW - Immunosuppressive Agents

KW - Inflammatory Bowel Diseases

KW - Leukocyte Count

KW - Logistic Models

KW - Male

KW - Methyltransferases

KW - Middle Aged

KW - Odds Ratio

KW - Retrospective Studies

KW - Treatment Failure

KW - Adult

KW - Azathioprine

KW - Biological Markers

KW - Erythrocytes

KW - Female

KW - Genotype

KW - Humans

KW - Immunosuppressive Agents

KW - Inflammatory Bowel Diseases

KW - Leukocyte Count

KW - Logistic Models

KW - Male

KW - Methyltransferases

KW - Middle Aged

KW - Odds Ratio

KW - Retrospective Studies

KW - Treatment Failure

UR - http://hdl.handle.net/10807/34633

M3 - Article

SN - 0269-2813

VL - 16

SP - 1743

EP - 1750

JO - ALIMENTARY PHARMACOLOGY & THERAPEUTICS

JF - ALIMENTARY PHARMACOLOGY & THERAPEUTICS

ER -

Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease

Abstract

Keywords

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