@article{7a164d4f962e47498783d5d50e4a08d6,
title = "Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease",
abstract = "Azathioprine therapy is discontinued in one-third of patients with inflammatory bowel disease because of toxicity or a lack of clinical response. Patients with thiopurine methyltransferase (TPMT) deficiency are intolerant to azathioprine, whilst carriers are at increased risk of side-effects.",
keywords = "Adult, Azathioprine, Biological Markers, Erythrocytes, Female, Genotype, Humans, Immunosuppressive Agents, Inflammatory Bowel Diseases, Leukocyte Count, Logistic Models, Male, Methyltransferases, Middle Aged, Odds Ratio, Retrospective Studies, Treatment Failure, Adult, Azathioprine, Biological Markers, Erythrocytes, Female, Genotype, Humans, Immunosuppressive Agents, Inflammatory Bowel Diseases, Leukocyte Count, Logistic Models, Male, Methyltransferases, Middle Aged, Odds Ratio, Retrospective Studies, Treatment Failure",
author = "A Ansari and Cesare Hassan and J Duley and A Marinaki and {Shobowale Bakre}, E and P Seed and J Meenan and A Yim and J. Sanderson",
year = "2002",
language = "English",
volume = "16",
pages = "1743--1750",
journal = "Alimentary Pharmacology and Therapeutics",
issn = "0269-2813",
publisher = "Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205",
}