TY - JOUR
T1 - Therapy for non-muscle invasive bladder cancer: HP-NAP
AU - D'Agostino, Daniele
AU - Racioppi, Marco
AU - Filianoti, Alessio
AU - Di Gianfrancesco, Luca
AU - Codolo, Gaia
AU - Fassan, Matteo
AU - Munari, Fabio
AU - Rugge, Massimo
AU - D'Elios, Mario Milco
AU - De Bernard, Marina
AU - Pagano, Francesco
AU - Bassi, Pierfrancesco
PY - 2012
Y1 - 2012
N2 - Purpose: Patients with non-muscle invasive bladder cancer recurrence after 2 induction courses of BCG are eligible for radical cystectomy. So, in the last years research to discover new drugs for the management of non-muscle invasive bladder cancer recurrence after failure of first and second line therapy is ongoing. In accordance to the results obtained with BCG, whose mechanism depends on the induction of the T helper 1 (TH1) immune response, we investigated the activity of a Toll-like receptor (TLR) 2 ligand, named Helicobacter Pylori Neutrophil Activating Protein (HP-NAP), that we recently demonstrated being able of enhancing the differentiation of Th1 cells, both in vitro and in vivo, because of its ability to create an IL-12 enriched milieu.
Materials and Methods: We show here, in a mouse model of bladder neoplasm implants, that local administration of HP-NAP decreases tumor growth by inducing tumor necrosis.
Results: The result is joined up with a massive cluster of both CD4+ and CD8+ IFN-γ+ cells, within neoplasm and regional lymph nodes. It is of note that HP-NAP-treated tumors show also a reduced vascularization due to the anti-angiogenic activity of IFN-γ induced by HP-NAP.
Conclusions: The present study suggeststhat the activity of HP-NAP against urothelial tumor burden warrants subsequent in vivo studies.
AB - Purpose: Patients with non-muscle invasive bladder cancer recurrence after 2 induction courses of BCG are eligible for radical cystectomy. So, in the last years research to discover new drugs for the management of non-muscle invasive bladder cancer recurrence after failure of first and second line therapy is ongoing. In accordance to the results obtained with BCG, whose mechanism depends on the induction of the T helper 1 (TH1) immune response, we investigated the activity of a Toll-like receptor (TLR) 2 ligand, named Helicobacter Pylori Neutrophil Activating Protein (HP-NAP), that we recently demonstrated being able of enhancing the differentiation of Th1 cells, both in vitro and in vivo, because of its ability to create an IL-12 enriched milieu.
Materials and Methods: We show here, in a mouse model of bladder neoplasm implants, that local administration of HP-NAP decreases tumor growth by inducing tumor necrosis.
Results: The result is joined up with a massive cluster of both CD4+ and CD8+ IFN-γ+ cells, within neoplasm and regional lymph nodes. It is of note that HP-NAP-treated tumors show also a reduced vascularization due to the anti-angiogenic activity of IFN-γ induced by HP-NAP.
Conclusions: The present study suggeststhat the activity of HP-NAP against urothelial tumor burden warrants subsequent in vivo studies.
KW - HP-NAP
KW - Tumore della Vescica
KW - HP-NAP
KW - Tumore della Vescica
UR - http://hdl.handle.net/10807/39605
U2 - 10.5301/RU.2012.9189
DO - 10.5301/RU.2012.9189
M3 - Articolo in rivista
SN - 0391-5603
VL - 79
SP - 142
EP - 148
JO - Urologia
JF - Urologia
ER -