Therapeutic implications of mesenchymal stem cells in liver injury

Wanda Lattanzi, Giovanni Battista Gasbarrini, Domenico D'Ugo, Antonio Gasbarrini, Maria Ausiliatrice Puglisi, Valentina Tesori, Anna Chiara Piscaglia

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Mesenchymal stem cells (MSCs), represent an attractive tool for the establishment of a successful stem-cell-based therapy of liver diseases. A number of different mechanisms contribute to the therapeutic effects exerted by MSCs, since these cells can differentiate into functional hepatic cells and can also produce a series of growth factors and cytokines able to suppress inflammatory responses, reduce hepatocyte apoptosis, regress liver fibrosis, and enhance hepatocyte functionality. To date, the infusion of MSCs or MSC-conditioned medium has shown encouraging results in the treatment of fulminant hepatic failure and in end-stage liver disease in experimental settings. However, some issues under debate hamper the use of MSCs in clinical trials. This paper summarizes the biological relevance of MSCs and the potential benefits and risks that can result from translating the MSC research to the treatment of liver diseases.
Lingua originaleEnglish
pagine (da-a)860578-860578
Numero di pagine1
RivistaJournal of Biomedicine and Biotechnology
Volume2011
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • liver injury
  • mesenchymal stem cells

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