The Ying and Yang of Hydrogen Sulfide as a Paracrine/Autocrine Agent in Neurodegeneration: Focus on Amyotrophic Lateral Sclerosis

Alida Spalloni, Susanna De Stefano, Juliette Gimenez, Viviana Greco, Nicola B. Mercuri, Valerio Chiurchiù, Patrizia Longone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Ever since its presence was reported in the brain, the nature and role of hydrogen sulfide (H2S) in the Central Nervous System (CNS) have changed. Consequently, H2S has been elected as the third gas transmitter, along with carbon monoxide and nitric oxide, and a number of studies have focused on its neuromodulatory and protectant functions in physiological conditions. The research on H2S has highlighted its many facets in the periphery and in the CNS, and its role as a double-faced compound, switching from protective to toxic depending on its concentration. In this review, we will focus on the bell-shaped nature of H2S as an angiogenic factor and as a molecule released by glial cells (mainly astrocytes) and non-neuronal cells acting on the surrounding environment (paracrine) or on the releasing cells themselves (autocrine). Finally, we will discuss its role in Amyotrophic Lateral Sclerosis, a paradigm of a neurodegenerative disease.
Lingua originaleEnglish
pagine (da-a)1-17
Numero di pagine17
RivistaCells
Volume12
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • astrocytes
  • hydrogen sulfide
  • oligodendrocytes
  • neurodegeneration
  • motor neuron

Fingerprint

Entra nei temi di ricerca di 'The Ying and Yang of Hydrogen Sulfide as a Paracrine/Autocrine Agent in Neurodegeneration: Focus on Amyotrophic Lateral Sclerosis'. Insieme formano una fingerprint unica.

Cita questo