The use of the OMERACT ultrasound tenosynovitis scoring system in multicenter clinical trials

Maria Antonietta D'Agostino; Mads Ammitzbøll-Danielsen; Mikkel Østergaard; Esperanza Naredo; Annamaria Iagnocco; Ingrid Möller; Maria-Antonietta D'Agostino; Frédérique Gandjbakhch; Lene Terslev

doi:10.3899/jrheum.170501

The use of the OMERACT ultrasound tenosynovitis scoring system in multicenter clinical trials

Maria Antonietta D'Agostino, Mads Ammitzbøll-Danielsen, Mikkel Østergaard, Esperanza Naredo, Annamaria Iagnocco, Ingrid Möller, Maria-Antonietta D'Agostino, Frédérique Gandjbakhch, Lene Terslev

Risultato della ricerca: Contributo in rivista › Articolo in rivista

3 Citazioni (Scopus)

Abstract

Objective: To test the sensitivity to change of the Outcome Measures in Rheumatology Clinical Trials (OMERACT) ultrasound (US) scoring system for tenosynovitis when applied in a multicenter design. Methods: RA patients with US-verified tenosynovitis were recruited when scheduled for treatment intensification. Tenosynovitis was assessed at baseline, and 3 and 6 months followup, using the semiquantitative OMERACT scoring system. Results: Expressed in median (25th; 75th percentiles), the overall greyscale and Doppler score decreased significantly from baseline at 4 (2; 7) and 3 (2; 6), to 6 months at 2 (0; 3) and 0 (0; 1, p < 0.01), respectively, and showed high responsiveness (standardized response mean = 0.8). Conclusion: The OMERACT US scoring system for tenosynovitis showed high responsiveness, supporting its use for diagnosing and monitoring tenosynovitis in multicenter trials.

Lingua originale	English
pagine (da-a)	165-169
Numero di pagine	5
Rivista	THE JOURNAL OF RHEUMATOLOGY
Volume	45
DOI	https://doi.org/10.3899/jrheum.170501
Stato di pubblicazione	Pubblicato - 2018

Keywords

Adult
Aged
Arthritis, Rheumatoid
C-Reactive Protein
Female
Follow-Up Studies
Health Surveys
Humans
Male
Middle Aged
Omeract
Outpatients
Pain Measurement
Research Design
Rheumatoid arthritis
Statistics, Nonparametric
Synovitis
Tenosynovitis
Ultrasonography
Ultrasonography, Doppler

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10.3899/jrheum.170501

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title = "The use of the OMERACT ultrasound tenosynovitis scoring system in multicenter clinical trials",

abstract = "Objective: To test the sensitivity to change of the Outcome Measures in Rheumatology Clinical Trials (OMERACT) ultrasound (US) scoring system for tenosynovitis when applied in a multicenter design. Methods: RA patients with US-verified tenosynovitis were recruited when scheduled for treatment intensification. Tenosynovitis was assessed at baseline, and 3 and 6 months followup, using the semiquantitative OMERACT scoring system. Results: Expressed in median (25th; 75th percentiles), the overall greyscale and Doppler score decreased significantly from baseline at 4 (2; 7) and 3 (2; 6), to 6 months at 2 (0; 3) and 0 (0; 1, p < 0.01), respectively, and showed high responsiveness (standardized response mean = 0.8). Conclusion: The OMERACT US scoring system for tenosynovitis showed high responsiveness, supporting its use for diagnosing and monitoring tenosynovitis in multicenter trials.",

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author = "D'Agostino, {Maria Antonietta} and Mads Ammitzb{\o}ll-Danielsen and Mikkel {\O}stergaard and Esperanza Naredo and Annamaria Iagnocco and Ingrid M{\"o}ller and Maria-Antonietta D'Agostino and Fr{\'e}d{\'e}rique Gandjbakhch and Lene Terslev",

year = "2018",

doi = "10.3899/jrheum.170501",

language = "English",

volume = "45",

pages = "165--169",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology:920 Yonge Street, Suite 115, Toronto Ontario M4W 3C7 Canada:(416)967-5155, EMAIL: jrheum@inforamp.com, INTERNET: http://jrheum.com, Fax: (416)967-7556",

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TY - JOUR

T1 - The use of the OMERACT ultrasound tenosynovitis scoring system in multicenter clinical trials

AU - D'Agostino, Maria Antonietta

AU - Ammitzbøll-Danielsen, Mads

AU - Østergaard, Mikkel

AU - Naredo, Esperanza

AU - Iagnocco, Annamaria

AU - Möller, Ingrid

AU - D'Agostino, Maria-Antonietta

AU - Gandjbakhch, Frédérique

AU - Terslev, Lene

PY - 2018

Y1 - 2018

N2 - Objective: To test the sensitivity to change of the Outcome Measures in Rheumatology Clinical Trials (OMERACT) ultrasound (US) scoring system for tenosynovitis when applied in a multicenter design. Methods: RA patients with US-verified tenosynovitis were recruited when scheduled for treatment intensification. Tenosynovitis was assessed at baseline, and 3 and 6 months followup, using the semiquantitative OMERACT scoring system. Results: Expressed in median (25th; 75th percentiles), the overall greyscale and Doppler score decreased significantly from baseline at 4 (2; 7) and 3 (2; 6), to 6 months at 2 (0; 3) and 0 (0; 1, p < 0.01), respectively, and showed high responsiveness (standardized response mean = 0.8). Conclusion: The OMERACT US scoring system for tenosynovitis showed high responsiveness, supporting its use for diagnosing and monitoring tenosynovitis in multicenter trials.

AB - Objective: To test the sensitivity to change of the Outcome Measures in Rheumatology Clinical Trials (OMERACT) ultrasound (US) scoring system for tenosynovitis when applied in a multicenter design. Methods: RA patients with US-verified tenosynovitis were recruited when scheduled for treatment intensification. Tenosynovitis was assessed at baseline, and 3 and 6 months followup, using the semiquantitative OMERACT scoring system. Results: Expressed in median (25th; 75th percentiles), the overall greyscale and Doppler score decreased significantly from baseline at 4 (2; 7) and 3 (2; 6), to 6 months at 2 (0; 3) and 0 (0; 1, p < 0.01), respectively, and showed high responsiveness (standardized response mean = 0.8). Conclusion: The OMERACT US scoring system for tenosynovitis showed high responsiveness, supporting its use for diagnosing and monitoring tenosynovitis in multicenter trials.

KW - Adult

KW - Aged

KW - Arthritis, Rheumatoid

KW - C-Reactive Protein

KW - Female

KW - Follow-Up Studies

KW - Health Surveys

KW - Humans

KW - Male

KW - Middle Aged

KW - Omeract

KW - Outpatients

KW - Pain Measurement

KW - Research Design

KW - Rheumatoid arthritis

KW - Statistics, Nonparametric

KW - Synovitis

KW - Tenosynovitis

KW - Ultrasonography

KW - Ultrasonography, Doppler

KW - Adult

KW - Aged

KW - Arthritis, Rheumatoid

KW - C-Reactive Protein

KW - Female

KW - Follow-Up Studies

KW - Health Surveys

KW - Humans

KW - Male

KW - Middle Aged

KW - Omeract

KW - Outpatients

KW - Pain Measurement

KW - Research Design

KW - Rheumatoid arthritis

KW - Statistics, Nonparametric

KW - Synovitis

KW - Tenosynovitis

KW - Ultrasonography

KW - Ultrasonography, Doppler

UR - http://hdl.handle.net/10807/168587

U2 - 10.3899/jrheum.170501

DO - 10.3899/jrheum.170501

M3 - Article

VL - 45

SP - 165

EP - 169

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

ER -

The use of the OMERACT ultrasound tenosynovitis scoring system in multicenter clinical trials

Abstract

Keywords

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