The UltraSound-CLinical ARthritis Activity (US-CLARA) index: Properties of a new composite disease activity index for rheumatoid arthritis.

Elisa Gremese, Anna Laura Fedele, Gianfranco Ferraccioli, Fausto Salaffi, Marco Di Carlo, Florenzo Iannone, Oscar Massimiliano Epis, Raffaele Pellerito, Rosario Foti, Giuseppe Passiu, Leonardo Punzi, Federica Furini, Piercarlo Sarzi-Puttini, Antonio Carletto, Giovanni Lapadula

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

Objective: To assess validity, responsiveness and interpretability of the UltraSound-CLinical ARthritis Activity (US-CLARA) index in patients with rheumatoid arthritis (RA). Methods: In this longitudinal study were involved RA patients starting treatment with abatacept. Subjects were followed along three visits in the first 6 months of therapy and underwent a comprehensive clinimetric evaluation. Validity was explored correlating the baseline scores and the cumulative inflammatory burden of the US-CLARA with the other composite indices applied. Sensitivity to change was assessed after 6 months of treatment in terms of internal and external responsiveness. Interpretability was defined in terms of determination of cutoffs against external criteria for remission (REM), low disease activity (LDA), moderate disease activity (MDA), and high disease activity (HDA) of SDAI. Results: One-hundred and thirty patients completed the study. Validity: moderate correlations were observed between US-CLARA and both DAS28-CRP and DAS28-ESR. Higher correlations were also found between US-CLARA and both SDAI and CDAI scores. Responsiveness: internal responsiveness was wide, with SRM and ES ranging from 0.91 to 1.51. US-CLARA responsiveness was similar to that of DAS28, SDAI, or CDAI. Similarly, the area under ROC curve (AUC-ROC) of US-CLARA gives identical results. The AUC of cumulative inflammatory burden, calculated during the 6-months follow-up of all combinations were highly correlated (p < 0.0001). Interpretability: cutoff values for REM, US-CLARA <2.0; for LDA, 2.0 ≤US-CLARA <3; for MDA, 3 ≤US-CLARA ≤4.8; for HDA, US-CLARA >4.8. Conclusion: The US-CLARA is valid and sensitive tool to assess disease activity in RA.
Lingua originaleEnglish
pagine (da-a)619-629
Numero di pagine11
RivistaSEMINARS IN ARTHRITIS AND RHEUMATISM
Volume47
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Anesthesiology and Pain Medicine
  • Biological therapies
  • Outcome measures
  • Rheumatoid arthritis
  • Rheumatology
  • Ultrasonography

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