The TRPM7 channel kinase: rekindling an old flame or not?

Far from being an accidental evolutional step, the\r\nfusion of a channel pore with a kinase domain within the TRPM7 molecule\r\nrepresents an optimized and integrated unit, able to couple\r\nextracellular sensing to intracellular signalling. The article by Rios\r\net al. strongly implicates both TRPM7 kinase and Mg2+ homeostasis\r\nin cardiovascular health, but before these findings may achieve\r\ntranslational relevance, it is imperative to dissect all the underlying\r\nmolecular mysteries.