Abstract
Far from being an accidental evolutional step, the
fusion of a channel pore with a kinase domain within the TRPM7 molecule
represents an optimized and integrated unit, able to couple
extracellular sensing to intracellular signalling. The article by Rios
et al. strongly implicates both TRPM7 kinase and Mg2+ homeostasis
in cardiovascular health, but before these findings may achieve
translational relevance, it is imperative to dissect all the underlying
molecular mysteries.
Lingua originale | English |
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pagine (da-a) | N/A-N/A |
Rivista | Cardiovascular Research |
DOI | |
Stato di pubblicazione | Pubblicato - 2019 |
Keywords
- TRPM7, inflammation, cardiovascular function