The treatment of hyperinsulinemic hypoglycaemia in adults: an update

Alfredo Pontecorvi, Antonio Bianchi, Laura De Marinis Grasso, M. V. Davi′, A. Pia, V. Guarnotta, G. Pizza, A. Colao, A. Faggiano, On Behalf Of Nike Group, Manuela Albertelli, Emanuela Arvat, Roberto Baldelli, Alfredo Berruti, Lisa Bodei, Gerardo Botti, Francesco Corcione, Gianfranco Delle Fave, Laura De Marinis, Gaetano De RosaAntonella Di Sarno, Alessandra Dicitore, Nicola Fazio, Giuseppe Fanciulli, Piero Ferolla, Diego Ferone, Angelina Filice, Marco Gallo, Carla Giordano, Dario Giuffrida, Andrea Lania, Secondo Lastoria, Francesco Logoluso, Paola Loli, Pasqualino Malandrino, Marco Manzoni, Massimo Marchetti, Chiara Martini, Erika Messina, Roberta Modica, Cecilia Motta, Mauro Papotti, Stefano Partelli, Giovanni Persico, Alessandro Piovesan, Valeria Ramundo, Paola Razzore, Francesca Rota, Francesco Scavuzzo, Concetta Sciammarella, Giovanni Vitale, Maria Chiara Zatelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

19 Citazioni (Scopus)

Abstract

Background: Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH. Methods: A search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed. Results: One hundred and forty articles were selected and analysed focusing on the most recent treatments of HH. Conclusions: New approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local–regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia.
Lingua originaleEnglish
pagine (da-a)9-20
Numero di pagine12
RivistaJournal of Endocrinological Investigation
Volume40
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Autoimmune hypoglycaemia
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hyperinsulinemic hypoglycaemia
  • Insulinoma
  • Nesidioblastosis
  • Treatment

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