[The treatment of hepatocellular carcinoma: an update]

Maurizio Pompili, Giovanni Battista Gasbarrini, Luca Miele, Antonio Grieco, Vittoria Vero, Simona Racco, Marco Biolato

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Hepatocellular carcinoma (HCC) is the third most frequent cause of death from cancer with an increasing incidence in the world. Hepatic cirrhosis is the main risk factor for the development of this tumor, present in more than 80% of cases. The prognosis of this tumor is still poor and appears to be strictly related to liver residual function and tumor extension. A regular surveillance program was defined to increase early detection of tumor in cirrhotic patients when curative treatment could be applied. Liver transplantation and liver resection offer a high rate of positive response when applied in a early stage of the disease; locoregional therapies are effective, palliative options for patients with unresectable HCC: transarterial chemoembolisation being the only with a proven positive impact on survival. Several prognostic systems are proposed in the last years to stratify patients in different risk groups and to identify those who could achieve the best survival benefit from different therapeutic strategies: the Okuda system, the Cancer of the Liver Italian Program and the Barcelona Clínic Liver Cancer are the most widely used, but there is no consensus to which is the best in predicting outcome most accurately.
Titolo tradotto del contributo[Autom. eng. transl.] [The treatment of hepatocellular carcinoma: an update]
Lingua originaleItalian
pagine (da-a)173-193
Numero di pagine21
RivistaMinerva Medica
Volume100
Stato di pubblicazionePubblicato - 2009

Keywords

  • Antineoplastic Agents
  • Brachytherapy
  • Carcinoma, Hepatocellular
  • Embolization, Therapeutic
  • Hepatectomy
  • Humans
  • Liver Neoplasms
  • Liver Transplantation
  • Neoplasm Staging
  • Prognosis

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