The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors

Barbara Fazi, Pasquale De Bonis, Carmelo Anile, Emilia Luca, Giulio Maira, Annunziato Mangiola, Armando Felsani, Luigi Grassi, Anna Moles, Daniel D'Andrea, Nicola Toschi, Daria Sicari, Maria Giovanna Guerrisi, Maria Giulia Farace, Silvia Anna Ciafré

Risultato della ricerca: Contributo in rivistaArticolo in rivista

23 Citazioni (Scopus)

Abstract

Glioblastoma multiforme (GBM) is the most common and deadliest primary brain tumor, driving patients to death within 15 months after diagnosis (short term survivors, ST), with the exception of a small fraction of patients (long term survivors, LT) surviving longer than 36 months. Here we present deep sequencing data showing that peritumoral (P) areas differ from healthy white matter, but share with their respective frankly tumoral (C) samples, a number of mRNAs and microRNAs representative of extracellular matrix remodeling, TGFβ and signaling, of the involvement of cell types different from tumor cells but contributing to tumor growth, such as microglia or reactive astrocytes. Moreover, we provide evidence about RNAs differentially expressed in ST vs LT samples, suggesting the contribution of TGF-β signaling in this distinction too. We also show that the edited form of miR-376c-3p is reduced in C vs P samples and in ST tumors compared to LT ones. As a whole, our study provides new insights into the still puzzling distinction between ST and LT tumors, and sheds new light onto that "grey" zone represented by the area surrounding the tumor, which we show to be characterized by the expression of several molecules shared with the proper tumor mass
Lingua originaleEnglish
pagine (da-a)22526-52-22552
RivistaOncotarget
Volume6
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • TGFβ
  • editing
  • glioblastoma
  • microRNA
  • peritumoral area

Fingerprint

Entra nei temi di ricerca di 'The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors'. Insieme formano una fingerprint unica.

Cita questo