The third nerve transection and regeneration in rats with preliminary results on the sixth nerve transection and regeneration in guinea pigs

Roberto Pallini, Eduardo Marcos Fernandez Marquez, Carlo Gangitano, Aurora Del Fa' Gangitano, Alessandro Sbriccoli, C Olivieri Sangiacomo, F Draicchio, G Talamonti, Ve Pettorossi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

The relationship between the phenomenon of the nonselective reinnervation and the functional recovery after section and repair of the highly organized third cranial nerve motor system in rats was studied. The same relationship after section and repair of the more simply organized sixth cranial nerve motor system in guinea pigs is presented as preliminary results. Anatomical demonstration of nonselective reinnervation was obtained by injecting horseradish peroxidase (HRP) into the extraocular muscles. A bilateral reinnervation of previously ipsilateral innervated muscles both in the third and the sixth nerve was interpreted as a plastic response of the brain stem neurons to the nerve injury. Functional recovery, evaluated by measuring with an infrared light technique the horizontal and vertical vestibulo-ocular reflexes, was excellent for the rectus lateralis muscle while it was relatively poor i.e. partial for the muscles depending on the third nerve. These data suggest that one of the most important factors influencing the functional recovery after section and repair of a peripheral nerve is the complexity of the nerve motor system organization.
Lingua originaleEnglish
pagine (da-a)221-224
Numero di pagine4
RivistaNeurological Research
Volume10
Stato di pubblicazionePubblicato - 1988

Keywords

  • Abducens Nerve
  • Animals
  • Guinea Pigs
  • Nerve Regeneration
  • Oculomotor Nerve
  • Rats
  • Rats, Inbred Strains
  • Reflex, Vestibulo-Ocular

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