The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data.

Giovanni Addolorato, Antonio Gasbarrini, Lorenzo Leggio, Anna Ferulli, Fabio Caputo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

59 Citazioni (Scopus)

Abstract

There is an increasing interest in studying the role of GABAergic medications in the treatment of alcohol dependence. The GABAergic drug gamma-hydroxybutyric acid (GHB) has been investigated in Europe as a possible treatment for alcohol dependence. In some European Countries, GHB has been approved as a treatment for alcohol dependence. However, this drug has also shown addictive properties, therefore raising questions about its safety in treating alcohol-dependent subjects. More recent research is focusing on the possibility of identifying alcohol-dependent subtypes without risk of developing GHB abuse. Finally, GHB and naltrexone combined together represent a possible approach deserving future investigations.
Lingua originaleEnglish
pagine (da-a)675-686
Numero di pagine12
RivistaExpert Opinion on Investigational Drugs
Stato di pubblicazionePubblicato - 2009

Keywords

  • gamma-hydroxybutyric acid

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