The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data

Giovanni Addolorato, Giovanni Battista Gasbarrini, Lorenzo Leggio, Anna Ferrulli, Fabio Caputo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

There is an increasing interest in studying the role of GABAergic medications in the treatment of alcohol dependence. The GABAergic drug gamma-hydroxybutyric acid (GHB) has been investigated in Europe as a possible treatment for alcohol dependence. In some European Countries, GHB has been approved as a treatment for alcohol dependence. However, this drug has also shown addictive properties, therefore raising questions about its safety in treating alcohol-dependent subjects. More recent research is focusing on the possibility of identifying alcohol-dependent subtypes without risk of developing GHB abuse. Finally, GHB and naltrexone combined together represent a possible approach deserving future investigations.
Lingua originaleEnglish
pagine (da-a)675-686
Numero di pagine12
RivistaExpert Opinion on Investigational Drugs
Volume18
Stato di pubblicazionePubblicato - 2009

Keywords

  • alcohol dependence
  • gamma-hydroxybutyric acid

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