The spontaneous fluctuation of the excitability of a single node modulates the internodes connectivity: a TMS-EEG study

Paolo Maria Rossini, Federica Giambattistelli, Leo Tomasevic, Giovanni Pellegrino, Camillo Porcaro, Jean Marc Melgari, Franca Tecchio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

17 Citazioni (Scopus)

Abstract

Brain effective connectivity can be tracked by cerebral recruitments evoked by transcranial magnetic stimulation (TMS), as measured by simultaneous electroencephalography (TMS-EEG). When TMS is targeting the primary motor area, motor evoked potentials (MEPs) can be collected from the "target" muscles. The aim of this study was to measure whether or not effective brain connectivity changes with the excitability level of the corticospinal motor pathway (CSMP) as parameterized by MEP amplitude. After averaging two subgroups of EEG-evoked responses corresponding to high and low MEP amplitudes, we calculated the individual differences between them and submitted the grand average to sLORETA algorithm obtaining localized regions of interest (RoIs). Statistical differences of RoI recruitment strength between low and high CSMP excitation was assessed in single subjects. Preceding the feedback arrival, neural recruitment for stronger CSMP activation were weaker at 6-10 ms of homotopic sensorimotor areas BA3/4/5 of the right nonstimulated hemisphere (trend), weaker at 18-25 ms of left parietal BA2/3/40, and stronger at 26-32 ms of bilateral frontal motor areas BA6/8. The proposed method enables the tracking of brain network connectivity during stimulation of one node by measuring the strength of the connected recruited node activations. Spontaneous increases of the excitation of the node originating the transmission within the hand control network gave rise to dynamic recruitment patterns with opposite behaviors, weaker in homotopic and parietal circuits, stronger in frontal ones. The effective connectivity within bilateral circuits orchestrating hand control appeared dynamically modulated in time even in resting state as probed by TMS.
Lingua originaleEnglish
pagine (da-a)1740-1749
Numero di pagine10
RivistaHuman Brain Mapping
Volume35
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Adult
  • Brain
  • Brain Mapping
  • Efferent Pathways
  • Electroencephalography
  • Evoked Potentials, Motor
  • Feedback, Physiological
  • Female
  • Hand
  • Humans
  • Male
  • Motor Cortex
  • Muscle, Skeletal
  • Spinal Cord
  • Transcranial Magnetic Stimulation
  • Young Adult
  • cerebral connectivity as localized cortical recruitment
  • spontaneous fluctuation of excitability
  • transcranial magnetic stimulation simultaneous to electroencephalographic recordings

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