TY - JOUR
T1 - The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): an overview
AU - Andrea, Silvestrini
AU - Alvaro, Mordente
AU - Martino, G
AU - Bruno, C
AU - Vergani, E
AU - Elisabetta, Meucci
AU - Antonio, Mancini
PY - 2020
Y1 - 2020
N2 - Selenium is a trace element, nutritionally classified as essential micronutrient, involved in maintaining the correct function of several enzymes incorporating the selenocysteine residue, namely the selenoproteins. The human selenoproteome including 25 proteins is here extensively described. The most relevant selenoproteins, including glutathione peroxidases, thioredoxin reductases and iodothyronine deiodinases are required for the proper cellular redox homeostasis as well as for the correct thyroid function, thus preventing oxidative stress and related diseases. This review summarizes the main advances on oxidative stress with a focus on selenium metabolism and transport. Moreover, thyroid-related disorders are discussed, considering that the thyroid gland contains the highest selenium amount per gram of tissue, also for future possible therapeutic implication
AB - Selenium is a trace element, nutritionally classified as essential micronutrient, involved in maintaining the correct function of several enzymes incorporating the selenocysteine residue, namely the selenoproteins. The human selenoproteome including 25 proteins is here extensively described. The most relevant selenoproteins, including glutathione peroxidases, thioredoxin reductases and iodothyronine deiodinases are required for the proper cellular redox homeostasis as well as for the correct thyroid function, thus preventing oxidative stress and related diseases. This review summarizes the main advances on oxidative stress with a focus on selenium metabolism and transport. Moreover, thyroid-related disorders are discussed, considering that the thyroid gland contains the highest selenium amount per gram of tissue, also for future possible therapeutic implication
KW - topoisomerases
KW - topoisomerases
UR - https://publicatt.unicatt.it/handle/10807/120833
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85079911118&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079911118&origin=inward
U2 - 10.2174/0929867325666180201111159
DO - 10.2174/0929867325666180201111159
M3 - Article
SN - 0929-8673
VL - 27
SP - 423
EP - 449
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 3
ER -