The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): an overview

Silvestrini Andrea; Mordente Alvaro; G Martino; C Bruno; E Vergani; Meucci Elisabetta; Mancini Antonio

doi:10.2174/0929867325666180201111159

The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): an overview

Silvestrini Andrea, Mordente Alvaro^*, G Martino, C Bruno, E Vergani, Meucci Elisabetta, Mancini Antonio

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo › peer review

3 Citazioni (Scopus)

Abstract

Selenium is a trace element, nutritionally classified as essential micronutrient, involved in maintaining the correct function of several enzymes incorporating the selenocysteine residue, namely the selenoproteins. The human selenoproteome including 25 proteins is here extensively described. The most relevant selenoproteins, including glutathione peroxidases, thioredoxin reductases and iodothyronine deiodinases are required for the proper cellular redox homeostasis as well as for the correct thyroid function, thus preventing oxidative stress and related diseases. This review summarizes the main advances on oxidative stress with a focus on selenium metabolism and transport. Moreover, thyroid-related disorders are discussed, considering that the thyroid gland contains the highest selenium amount per gram of tissue, also for future possible therapeutic implication

Lingua originale	Inglese
pagine (da-a)	423-449
Numero di pagine	27
Rivista	Current Medicinal Chemistry
Volume	27
Numero di pubblicazione	3
DOI	https://doi.org/10.2174/0929867325666180201111159
Stato di pubblicazione	Pubblicato - 2020
Pubblicato esternamente	Sì

All Science Journal Classification (ASJC) codes

Biochimica
Medicina Molecolare
Farmacologia
Nuovi Farmaci
Chimica Organica

Keywords

topoisomerases

OSS delle Nazioni Unite

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10.2174/0929867325666180201111159

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abstract = "Selenium is a trace element, nutritionally classified as essential micronutrient, involved in maintaining the correct function of several enzymes incorporating the selenocysteine residue, namely the selenoproteins. The human selenoproteome including 25 proteins is here extensively described. The most relevant selenoproteins, including glutathione peroxidases, thioredoxin reductases and iodothyronine deiodinases are required for the proper cellular redox homeostasis as well as for the correct thyroid function, thus preventing oxidative stress and related diseases. This review summarizes the main advances on oxidative stress with a focus on selenium metabolism and transport. Moreover, thyroid-related disorders are discussed, considering that the thyroid gland contains the highest selenium amount per gram of tissue, also for future possible therapeutic implication",

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AU - Andrea, Silvestrini

AU - Alvaro, Mordente

AU - Martino, G

AU - Bruno, C

AU - Vergani, E

AU - Elisabetta, Meucci

AU - Antonio, Mancini

PY - 2020

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N2 - Selenium is a trace element, nutritionally classified as essential micronutrient, involved in maintaining the correct function of several enzymes incorporating the selenocysteine residue, namely the selenoproteins. The human selenoproteome including 25 proteins is here extensively described. The most relevant selenoproteins, including glutathione peroxidases, thioredoxin reductases and iodothyronine deiodinases are required for the proper cellular redox homeostasis as well as for the correct thyroid function, thus preventing oxidative stress and related diseases. This review summarizes the main advances on oxidative stress with a focus on selenium metabolism and transport. Moreover, thyroid-related disorders are discussed, considering that the thyroid gland contains the highest selenium amount per gram of tissue, also for future possible therapeutic implication

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The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): an overview

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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