The role of radiotherapy in adult medulloblastoma: long-term single-institution experience and a review of the literature

Mario Balducci, Silvia Chiesa, Daniela Pia Rosaria Chieffo, Stefania Manfrida, Nicola Dinapoli, Alice Fiorentino, F. Miccichè, Vincenzo Frascino, Carmelo Anile, Vincenzo Valentini, B. De Bari

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Medulloblastoma (MB) occurs infrequently in adult patients and standard treatment is still controversial. We report our long-term, single-institution experience of adult MB and a review of the literature. We analysed adult patients with histologically proved MB treated by postoperative radiotherapy. Primary endpoints were local control (LC), disease-free survival (DFS), and overall survival (OS). Acute toxicity was reported according to CTC-NCI score vers. 3.0 and specific neuropsychological assessment analysis was performed to define late brain toxicity. From 1990-2008, 13 patients were treated by craniospinal (CSI, 12/13) or cranial irradiation (1/13, because of bad clinical conditions). Median follow up was 101 months (64-218). Complete radiological response was observed in 12/13 patients and a partial response in 1/13. Ten-year LC, OS, and DFS were 91, 76, and 84%, respectively. Two patients died because of local and spinal progression after 13 and 62 months. Acute G3 haematological toxicity (RTOG score) was observed for one patient only. The neuropsychological analysis did not reveal late toxicity related to brain radiotherapy. This experience confirms the efficacy and safety of radiotherapy in adult MB patients, resulting in very interesting 10-year LC and OS.
Lingua originaleEnglish
pagine (da-a)315-323
Numero di pagine9
RivistaJournal of Neuro-Oncology
Volume106
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adult medulloblastoma
  • Radiotherapy
  • Review
  • CSI
  • Toxicity
  • Cranio-spinal irradiation

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