The role of primary antifungal prophylaxis in patients with haematological malignancies

Risultato della ricerca: Contributo in rivistaArticolo in rivista

17 Citazioni (Scopus)

Abstract

Invasive fungal Infections (IFIs) represent important complications in patients with haematological malignancies. Chemoprevention of IFIs may play an important role in this setting, but in the past decades the majority of antifungal drugs utilized demonstrated poor efficacy, particularly in the prevention of invasive aspergillosis. The new triazoles are a very useful antifungal drugs, more suitable for prophylaxis of IFIs than amphotericin B and echinocandins. In this review the main clinical data about antifungal prophylaxis with fluconazole, itraconazole, voriconazole and posaconazole are analyzed. At present posaconazole was appears to be the most efficacious azole in antifungal prophylaxis, particularly in patients with acute myeloid leukaemia.
Lingua originaleEnglish
pagine (da-a)19-26
Numero di pagine8
RivistaClinical Microbiology and Infection
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • antifungal prophylaxis
  • leukemia

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