TY - JOUR
T1 - The role of primary antifungal prophylaxis in patients with haematological malignancies
AU - Pagano, Livio
AU - Caira, M.
PY - 2013
Y1 - 2013
N2 - Invasive fungal Infections (IFIs) represent important complications in patients with haematological malignancies. Chemoprevention of IFIs may play an important role in this setting, but in the past decades the majority of antifungal drugs utilized demonstrated poor efficacy, particularly in the prevention of invasive aspergillosis. The new triazoles are a very useful antifungal drugs, more suitable for prophylaxis of IFIs than amphotericin B and echinocandins. In this review the main clinical data about antifungal prophylaxis with fluconazole, itraconazole, voriconazole and posaconazole are analyzed. At present posaconazole was appears to be the most efficacious azole in antifungal prophylaxis, particularly in patients with acute myeloid leukaemia.
AB - Invasive fungal Infections (IFIs) represent important complications in patients with haematological malignancies. Chemoprevention of IFIs may play an important role in this setting, but in the past decades the majority of antifungal drugs utilized demonstrated poor efficacy, particularly in the prevention of invasive aspergillosis. The new triazoles are a very useful antifungal drugs, more suitable for prophylaxis of IFIs than amphotericin B and echinocandins. In this review the main clinical data about antifungal prophylaxis with fluconazole, itraconazole, voriconazole and posaconazole are analyzed. At present posaconazole was appears to be the most efficacious azole in antifungal prophylaxis, particularly in patients with acute myeloid leukaemia.
KW - antifungal prophylaxis
KW - leukemia
KW - antifungal prophylaxis
KW - leukemia
UR - http://hdl.handle.net/10807/50416
U2 - 10.1111/1469-0691.12464
DO - 10.1111/1469-0691.12464
M3 - Article
SN - 1198-743X
SP - 19
EP - 26
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
ER -