TY - JOUR
T1 - The role of PET/CT in connective tissue disorders: systemic sclerosis, Sjögren's syndrome and systemic lupus erythematosus
AU - Guarneri, Andrea
AU - Perrone, Elisabetta
AU - Bosello, Silvia Laura
AU - D'Agostino, Maria Antonietta
AU - Leccisotti, Lucia
PY - 2022
Y1 - 2022
N2 - Advanced imaging techniques are needed to help clinicians in the diagnosis, in the choice of the right time for therapeutic interventions or for modifications and monitoring of treatment response in patients with autoimmune connective tissue diseases. Nuclear medicine imaging, espe-cially PET/CT and PET/MRI, may play an important role in detecting disease activity, assessing early treatment response as well as in clarifying the complex mechanisms underlying systemic sclerosis, Sjogren's syndrome or systemic lupus erythematosus. In addition, [18F]FDG PET/CT may help in excluding or detecting coexisting malignancies. Other more specific radiopharmaceuticals are being developed and investigated, targeting specific cells and molecules involved in connective tissue diseases. Further larger studies with standardized imaging protocol and im-age interpretation are strongly required before including PET/CT in the diagnostic work-up of subsets of patients with autoimmune connective tissue diseases.
AB - Advanced imaging techniques are needed to help clinicians in the diagnosis, in the choice of the right time for therapeutic interventions or for modifications and monitoring of treatment response in patients with autoimmune connective tissue diseases. Nuclear medicine imaging, espe-cially PET/CT and PET/MRI, may play an important role in detecting disease activity, assessing early treatment response as well as in clarifying the complex mechanisms underlying systemic sclerosis, Sjogren's syndrome or systemic lupus erythematosus. In addition, [18F]FDG PET/CT may help in excluding or detecting coexisting malignancies. Other more specific radiopharmaceuticals are being developed and investigated, targeting specific cells and molecules involved in connective tissue diseases. Further larger studies with standardized imaging protocol and im-age interpretation are strongly required before including PET/CT in the diagnostic work-up of subsets of patients with autoimmune connective tissue diseases.
KW - Positron emission tomography computed tomography
KW - Fluorodeoxyglucose F18
KW - Lupus erythematosus
KW - systemic
KW - Sjogren's syndrome
KW - Scleroderma
KW - Positron emission tomography computed tomography
KW - Fluorodeoxyglucose F18
KW - Lupus erythematosus
KW - systemic
KW - Sjogren's syndrome
KW - Scleroderma
UR - http://hdl.handle.net/10807/237737
U2 - 10.23736/S1824-4785.22.03463-X
DO - 10.23736/S1824-4785.22.03463-X
M3 - Article
SN - 1824-4785
VL - 66
SP - 194
EP - 205
JO - THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
JF - THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
ER -