Abstract
Zygomycosis constitutes the third leading cause of invasive fungal infections following aspergillosis and candidosis. Patients with haematologic
malignancies or haematopoietic stem cell transplantation are particularly susceptible to zygomycosis. Neutropenia represents the
most important pathogenic mechanism influencing the onset and outcome of zygomycosis. Neutrophils cause a lesion of the fungal wall
with subsequent destruction by macrophages. They also enhance the activity of antifungal drugs against Zygomycetes. Strategies that
aim to increase neutrophil count and function, such as granulocyte colony stimulating factor and granulocyte transfusion, could play an
important role in the management of this life-threatening infectious complication.
Lingua originale | English |
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pagine (da-a) | 33-36 |
Numero di pagine | 4 |
Rivista | Clinical Microbiology and Infection |
Volume | 15 |
Stato di pubblicazione | Pubblicato - 2009 |
Keywords
- leucemia
- zigomicosi