@article{b738c822501d418bbfcfaf6efc5c2b14,
title = "The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue",
abstract = "In the last years, the influence of different genes involved in metabolism of chemotherapeutic agents has been studied. Methotrexate (MTX) is a key compound of chemotherapeutic regimens used in the treatment of acute lymphoblastic leukemia (ALL), primary central nervous system lymphoma (PCNSL) and Burkitt's lymphomas (BL). This study aims to evaluate the role of MTHFR C677T and A1298C polymorphisms and G80A reduced folate carrier gene (RFC1) in a cohort of adult patients with lymphoproliferative malignancies submitted to high-dose MTX followed by leucovorin rescue.",
keywords = "Adolescent, Adult, Aged, Animals, Antineoplastic Combined Chemotherapy Protocols, Cohort Studies, Disease-Free Survival, Hematologic Neoplasms, Humans, Kaplan-Meier Estimate, Leucovorin, Male, Methotrexate, Methylenetetrahydrofolate Reductase (NADPH2), Middle Aged, Polymorphism, Genetic, Reduced Folate Carrier Protein, Young Adult, Adolescent, Adult, Aged, Animals, Antineoplastic Combined Chemotherapy Protocols, Cohort Studies, Disease-Free Survival, Hematologic Neoplasms, Humans, Kaplan-Meier Estimate, Leucovorin, Male, Methotrexate, Methylenetetrahydrofolate Reductase (NADPH2), Middle Aged, Polymorphism, Genetic, Reduced Folate Carrier Protein, Young Adult",
author = "Patrizia Chiusolo and Nicola Piccirillo and Luca Laurenti and Stefan Hohaus and Simona Sica and Sabrina Giammarco and Silvia Bellesi and Elisabetta Metafuni and {De Ritis}, {Daniela Giovanna} and Sara Marietti and Luana Fianchi and Giuseppe Leone and S Federica",
year = "2012",
doi = "10.1007/s00280-011-1751-4",
language = "English",
volume = "69",
pages = "691--696",
journal = "Cancer Chemotherapy and Pharmacology",
issn = "0344-5704",
publisher = "Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229",
}