The role of IL-15 in gastrointestinal diseases: a bridge between innate and adaptive immune response

Rossella Cianci, Giovanni Cammarota, Danilo Pagliari, Simona Frosali, Raffaele Landolfi, Franco Pandolfi, Estelle E. Newton

Risultato della ricerca: Contributo in rivistaArticolo in rivista

33 Citazioni (Scopus)

Abstract

IL-15 is a member of the IL-2 family of cytokines whose signaling pathways are a bridge between innate and adaptive immune response. IL-15 is part of the intestinal mucosal barrier, and functions to modulate gut homeostasis. IL-15 has pivotal roles in the control of development, proliferation and survival of both innate and adaptive immune cells. IL-15 becomes up-regulated in the inflamed tissue of intestinal inflammatory disease, such as IBD, Celiac Disease and related complications. Indeed, several studies have reported that IL-15 may participate to the pathogenesis of these diseases. Furthermore, although IL-15 seems to be responsible for inflammation and autoimmunity, it also may increase the immune response against cancer. For these reasons, we decided to study the intestinal mucosa as an 'immunological niche', in which immune response, inflammation and local homeostasis are modulated. Understanding the role of the IL-15/IL-15R system will provide a scientific basis for the development of new approaches that use IL-15 for immunotherapy of autoimmune diseases and malignancies. Indeed, a better understanding of the complexity of the mucosal immune system will contribute to the general understanding of immuno-pathology, which could lead to new therapeutical tools for widespread immuno-mediated diseases.
Lingua originaleEnglish
pagine (da-a)455-466
Numero di pagine12
RivistaCYTOKINE & GROWTH FACTOR REVIEWS
Stato di pubblicazionePubblicato - 2013

Keywords

  • IL-15
  • gastrointestinal diseases
  • immunity

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