The role of HLA--G 14-bp polymorphism in allo-HSCT after short-term course MTX for GvHD prophylaxis

Patrizia Chiusolo, Nicola Piccirillo, Simona Sica, Silvia Bellesi, Sabrina Giammarco, Sara Marietti, Elisabetta Metafuni, Giuseppe Leone, D De Ritis, M Stignani, Or Baricordi, R. Rizzo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

26 Citazioni (Scopus)

Abstract

HLA-G molecules are HLA class Ib antigens characterized by tolerogenic and immunoinhibitory functions. The HLA-G 14-bp insertion/deletion (ins/del) polymorphism controls protein expression and seems to be implicated in both MTX treatment response and SCT outcome. The aim of our study is to evaluate the role of HLA-G 14 bp polymorphism in subjects affected by hematological malignancies undergoing allo-SCT and receiving MTX therapy for GvHD prophylaxis. We performed a retrospective analysis of HLA-G 14 bp polymorphism using a specific PCR in 47 recipients and in their respective donors, and evaluated the correlation with the incidence of aGvHD, OS and disease-free survival (DFS) after allo-SCT. We did not observe any correlation between this polymorphism and the risk of aGvHD occurrence. On the contrary, we found that the recipients with a 14 bp ins/14 bp ins genotype were characterized by a lower OS and DFS in univariate and multivariate analysis (OS=OR: 3.235; DFS=OR: 3.302). These data indicate a role for recipient HLA-G 14 bp polymorphism in allo-SCT immunotolerance status and follow-up.
Lingua originaleEnglish
pagine (da-a)120-124
Numero di pagine5
RivistaBone Marrow Transplantation
Volume47
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adolescent
  • Adult
  • Child
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Graft vs Host Disease
  • HLA-G Antigens
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • INDEL Mutation
  • Immunosuppressive Agents
  • Leukemia, Myeloid, Acute
  • Male
  • Methotrexate
  • Middle Aged
  • Polymorphism, Genetic
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Retrospective Studies
  • Survival Rate
  • Time Factors
  • Transplantation, Homologous

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