The role of HLA--G 14-bp polymorphism in allo-HSCT after short-term course MTX for GvHD prophylaxis

Patrizia Chiusolo, Silvia Bellesi, Nicola Piccirillo, Sabrina Giammarco, Sara Marietti, D. De Ritis, Elisabetta Metafuni, M. Stignani, O. R. Baricordi, Simona Sica, Giuseppe Leone, R. Rizzo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

27 Citazioni (Scopus)


HLA-G molecules are HLA class Ib antigens characterized by tolerogenic and immunoinhibitory functions. The HLA-G 14-bp insertion/deletion (ins/del) polymorphism controls protein expression and seems to be implicated in both MTX treatment response and SCT outcome. The aim of our study is to evaluate the role of HLA-G 14 bp polymorphism in subjects affected by hematological malignancies undergoing allo-SCT and receiving MTX therapy for GvHD prophylaxis. We performed a retrospective analysis of HLA-G 14 bp polymorphism using a specific PCR in 47 recipients and in their respective donors, and evaluated the correlation with the incidence of aGvHD, OS and disease-free survival (DFS) after allo-SCT. We did not observe any correlation between this polymorphism and the risk of aGvHD occurrence. On the contrary, we found that the recipients with a 14 bp ins/14 bp ins genotype were characterized by a lower OS and DFS in univariate and multivariate analysis (OS=OR: 3.235; DFS=OR: 3.302). These data indicate a role for recipient HLA-G 14 bp polymorphism in allo-SCT immunotolerance status and follow-up.
Lingua originaleEnglish
pagine (da-a)120-124
Numero di pagine5
RivistaBone Marrow Transplantation
Stato di pubblicazionePubblicato - 2012


  • Adolescent
  • Adult
  • Child
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Graft vs Host Disease
  • HLA-G Antigens
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • INDEL Mutation
  • Immunosuppressive Agents
  • Leukemia, Myeloid, Acute
  • Male
  • Methotrexate
  • Middle Aged
  • Polymorphism, Genetic
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Retrospective Studies
  • Survival Rate
  • Time Factors
  • Transplantation, Homologous


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