The Role of Growth Hormone Receptor Isoforms and Their Effects in Bone Metabolism and Skeletal Fragility

Sabrina Chiloiro; Federica Mirra; Donfrancesco Federico; Antonella Giampietro; Felicia Visconti; Laura Rossi; Alfredo Pontecorvi; Laura De Marinis Grasso; Antonio Bianchi

doi:10.2174/0929866527666200616151105

The Role of Growth Hormone Receptor Isoforms and Their Effects in Bone Metabolism and Skeletal Fragility

Sabrina Chiloiro, Federica Mirra, Donfrancesco Federico, Antonella Giampietro, Felicia Visconti, Laura Rossi, Alfredo Pontecorvi, Laura De Marinis Grasso, Antonio Bianchi

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Acromegaly and Growth Hormone Deficiency (GHD) are associated with skeletal fragility and with an increased prevalence of Vertebral Fractures (VFs). In the most recent years, several authors tried to investigate surrogate markers that may predict the risk of bone fragility in these endocrine disorders. The aim of this review is to evaluate the role of GH receptor polymorphisms in skeletal fragility in patients affected by GHD and acromegaly. In fact, until now, two different isoforms of the GH Receptor (GHR) were described, that differ for the presence or the absence of transcription of the exon 3 of the GHR gene. Both the isoforms produce a functioning receptor, but the exon 3-deleted isoforms (d3-GHR) has a higher sensitivity to endogenous and recombinant GH as compared to the full-length isoform (fl-GHR).

Lingua originale	English
pagine (da-a)	1260-1267
Numero di pagine	8
Rivista	PROTEIN & PEPTIDE LETTERS
DOI	https://doi.org/10.2174/0929866527666200616151105
Stato di pubblicazione	Pubblicato - 2020

Keywords

Fracture

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10.2174/0929866527666200616151105

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title = "The Role of Growth Hormone Receptor Isoforms and Their Effects in Bone Metabolism and Skeletal Fragility",

abstract = "Acromegaly and Growth Hormone Deficiency (GHD) are associated with skeletal fragility and with an increased prevalence of Vertebral Fractures (VFs). In the most recent years, several authors tried to investigate surrogate markers that may predict the risk of bone fragility in these endocrine disorders. The aim of this review is to evaluate the role of GH receptor polymorphisms in skeletal fragility in patients affected by GHD and acromegaly. In fact, until now, two different isoforms of the GH Receptor (GHR) were described, that differ for the presence or the absence of transcription of the exon 3 of the GHR gene. Both the isoforms produce a functioning receptor, but the exon 3-deleted isoforms (d3-GHR) has a higher sensitivity to endogenous and recombinant GH as compared to the full-length isoform (fl-GHR).",

keywords = "Fracture, Fracture",

author = "Sabrina Chiloiro and Federica Mirra and Donfrancesco Federico and Antonella Giampietro and Felicia Visconti and Laura Rossi and Alfredo Pontecorvi and {De Marinis Grasso}, Laura and Antonio Bianchi",

year = "2020",

doi = "10.2174/0929866527666200616151105",

language = "English",

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journal = "PROTEIN & PEPTIDE LETTERS",

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T1 - The Role of Growth Hormone Receptor Isoforms and Their Effects in Bone Metabolism and Skeletal Fragility

AU - Chiloiro, Sabrina

AU - Mirra, Federica

AU - Federico, Donfrancesco

AU - Giampietro, Antonella

AU - Visconti, Felicia

AU - Rossi, Laura

AU - Pontecorvi, Alfredo

AU - De Marinis Grasso, Laura

AU - Bianchi, Antonio

PY - 2020

Y1 - 2020

N2 - Acromegaly and Growth Hormone Deficiency (GHD) are associated with skeletal fragility and with an increased prevalence of Vertebral Fractures (VFs). In the most recent years, several authors tried to investigate surrogate markers that may predict the risk of bone fragility in these endocrine disorders. The aim of this review is to evaluate the role of GH receptor polymorphisms in skeletal fragility in patients affected by GHD and acromegaly. In fact, until now, two different isoforms of the GH Receptor (GHR) were described, that differ for the presence or the absence of transcription of the exon 3 of the GHR gene. Both the isoforms produce a functioning receptor, but the exon 3-deleted isoforms (d3-GHR) has a higher sensitivity to endogenous and recombinant GH as compared to the full-length isoform (fl-GHR).

AB - Acromegaly and Growth Hormone Deficiency (GHD) are associated with skeletal fragility and with an increased prevalence of Vertebral Fractures (VFs). In the most recent years, several authors tried to investigate surrogate markers that may predict the risk of bone fragility in these endocrine disorders. The aim of this review is to evaluate the role of GH receptor polymorphisms in skeletal fragility in patients affected by GHD and acromegaly. In fact, until now, two different isoforms of the GH Receptor (GHR) were described, that differ for the presence or the absence of transcription of the exon 3 of the GHR gene. Both the isoforms produce a functioning receptor, but the exon 3-deleted isoforms (d3-GHR) has a higher sensitivity to endogenous and recombinant GH as compared to the full-length isoform (fl-GHR).

KW - Fracture

UR - http://hdl.handle.net/10807/188266

U2 - 10.2174/0929866527666200616151105

DO - 10.2174/0929866527666200616151105

M3 - Article

SN - 1875-5305

SP - 1260

EP - 1267

JO - PROTEIN & PEPTIDE LETTERS

JF - PROTEIN & PEPTIDE LETTERS

ER -

The Role of Growth Hormone Receptor Isoforms and Their Effects in Bone Metabolism and Skeletal Fragility

Abstract

Keywords

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