The Role of Focal Approach as Alternative to Nephron- Sparing Surgery in the Treatment of Stage I Cancer in Renal Graft: Results of a Systematic Review

Alessandro Posa, Valentina Lancellotta, Fabio Paoletti, Annalisa Tanzilli, Anna Acampora, Barbara Alicja Jereczek-Fossa, Maria Antonietta Gambacorta, Jacopo Romagnoli, Rosario Francesco Grasso, Andrea Veltri, Gyorgy Kovacs, Vincenzo Valentini, Riccardo Manfredi, Roberto Iezzi, Luca Tagliaferri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

In patients with kidney graft neoplasms, the treatment of choice is still represented by surgical approach, mainly based on partial nephrectomy/nephron sparing surgery (NSS). In this oncologic setting, focal treatments (FT) are becoming more and more useful to avoid the risk of dialysis, considering graft viability of utmost importance. There is still little evidence on which is the best FT option in kidney graft neoplasms and on its therapeutic indications. We performed a systematic review to assess the role of FT such as thermal ablation, interventional radiotherapy, electrochemotherapy, and stereotactic body radiotherapy, as alternative to NSS in the treatment of Stage I kidney cancer. We searched PubMed, Scopus, and Web of Science for articles published between 2010 and 2020 focusing on kidney transplant recipients with kidney graft neoplasm who had undergone FT. The review is framed by the population, intervention, control, and outcomes criteria. The studies underlined safety and efficacy of FT, with low morbidity and good graft survival, but none of them provided a direct comparison with graft nephrectomy or NSS. There is still no clear evidence that FTs, and percutaneous ones in particular, are indicated as a standard treatment in kidney graft neoplasms as opposed to total or partial graft nephrectomy.
Lingua originaleEnglish
pagine (da-a)351-360
Numero di pagine10
RivistaTÜRK ONKOLOJI DERGISI
Volume37
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • Focal treatment
  • graft rejection
  • nephron sparing surgery
  • renal transplant patients

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