The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting

Elisabetta Metafuni, Luca Di Marino, Sabrina Giammarco, Silvia Bellesi, Maria Assunta Limongiello, Federica Sora', Filippo Frioni, Roberto Maggi, Patrizia Chiusolo, Simona Sica

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host disease. This article aims to review the current knowledge about the close link between microbiota and allogeneic stem cell transplantation setting. The PubMed search engine was used to perform this review. We analyzed data on microbiota dysbiosis related to the above-mentioned affecting factors. We also looked at treatments aimed at modifying gut dysbiosis and applications of fecal microbiota transplantation in the allogeneic stem cell transplant field, with particular interest in fecal microbiota transplantation for graft-versus-host disease (GvHD), multidrug-resistant and clostridium difficile infections, and microbiota restoration after chemotherapy and antibiotic therapy.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaMicroorganisms
Volume11
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • allogeneic hematopoietic stem cell transplantation
  • clostridium difficile infection
  • diversity
  • probiotic
  • graft-versus-host disease
  • multi-drug resistant
  • prebiotic
  • fecal microbiota transplantation

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