The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

Tommaso Bizzarro; Maurizio Martini; C Marrocco; D D'Amato; Emanuela Traini; Celestino Pio Lombardi; Alfredo Pontecorvi; Guido Fadda; Luigi Maria Larocca; Esther Rossi

doi:10.1371/journal.pone.0132939

The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

Tommaso Bizzarro
, Maurizio Martini
, C Marrocco
, D D'Amato
, Emanuela Traini
, Celestino Pio Lombardi
, Alfredo Pontecorvi
, Guido Fadda
, Luigi Maria Larocca
, Esther Rossi

Risultato della ricerca: Contributo in rivista › Articolo

12 Citazioni (Scopus)

Abstract

Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.

Lingua originale	Inglese
pagine (da-a)	e0132939-e0132939
Rivista	PLoS One
Volume	10
Numero di pubblicazione	7
DOI	https://doi.org/10.1371/journal.pone.0132939
Stato di pubblicazione	Pubblicato - 2015

All Science Journal Classification (ASJC) codes

Multidisciplinare

Keywords

Fine Needle Aspiration

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10.1371/journal.pone.0132939

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abstract = "Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30\% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100\% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.",

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AU - Bizzarro, Tommaso

AU - Martini, Maurizio

AU - Marrocco, C

AU - D'Amato, D

AU - Traini, Emanuela

AU - Lombardi, Celestino Pio

AU - Pontecorvi, Alfredo

AU - Fadda, Guido

AU - Larocca, Luigi Maria

AU - Rossi, Esther

PY - 2015

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AB - Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.

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The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

Abstract

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