The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

Tommaso Bizzarro; Maurizio Martini; Carla Marrocco; Donato D'Amato; Emanuela Traini; Celestino Pio Lombardi; Alfredo Pontecorvi; Guido Fadda; Luigi Maria Larocca; Esther Rossi

doi:10.1371/journal.pone.0132939

The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

Tommaso Bizzarro, Maurizio Martini, Carla Marrocco, Donato D'Amato, Emanuela Traini, Celestino Pio Lombardi, Alfredo Pontecorvi, Guido Fadda, Luigi Maria Larocca, Esther Rossi

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Abstract

Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.

Lingua originale	Inglese
pagine (da-a)	e0132939-e0132939
Rivista	PLoS One
Volume	10
DOI	https://doi.org/10.1371/journal.pone.0132939
Stato di pubblicazione	Pubblicato - 2015

Keywords

Fine Needle Aspiration

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title = "The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology",

abstract = "Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.",

keywords = "Fine Needle Aspiration, Fine Needle Aspiration",

author = "Tommaso Bizzarro and Maurizio Martini and Carla Marrocco and Donato D'Amato and Emanuela Traini and Lombardi, {Celestino Pio} and Alfredo Pontecorvi and Guido Fadda and Larocca, {Luigi Maria} and Esther Rossi",

year = "2015",

doi = "10.1371/journal.pone.0132939",

language = "English",

volume = "10",

pages = "e0132939--e0132939",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

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TY - JOUR

T1 - The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

AU - Bizzarro, Tommaso

AU - Martini, Maurizio

AU - Marrocco, Carla

AU - D'Amato, Donato

AU - Traini, Emanuela

AU - Lombardi, Celestino Pio

AU - Pontecorvi, Alfredo

AU - Fadda, Guido

AU - Larocca, Luigi Maria

AU - Rossi, Esther

PY - 2015

Y1 - 2015

N2 - Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.

AB - Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.

KW - Fine Needle Aspiration

UR - http://hdl.handle.net/10807/70155

U2 - 10.1371/journal.pone.0132939

DO - 10.1371/journal.pone.0132939

M3 - Article

SN - 1932-6203

VL - 10

SP - e0132939-e0132939

JO - PLoS One

JF - PLoS One

ER -

The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

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