The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

Maurizio Martini; Celestino Pio Lombardi; Alfredo Pontecorvi; Luigi Maria Larocca; Esther Rossi; Tommaso Bizzarro; Emanuela Traini; Guido Fadda

doi:10.1371/journal.pone.0132939

The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

Maurizio Martini, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Esther Rossi, Tommaso Bizzarro, Emanuela Traini, Guido Fadda

Risultato della ricerca: Contributo in rivista › Articolo in rivista

12 Citazioni (Scopus)

Abstract

Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.

Lingua originale	English
pagine (da-a)	e0132939-e0132939
Rivista	PLoS One
Volume	10
DOI	https://doi.org/10.1371/journal.pone.0132939
Stato di pubblicazione	Pubblicato - 2015

Keywords

Fine Needle Aspiration

Accesso al documento

10.1371/journal.pone.0132939

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title = "The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology",

abstract = "Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.",

keywords = "Fine Needle Aspiration, Fine Needle Aspiration",

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The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology. / Martini, Maurizio ; Lombardi, Celestino Pio ; Pontecorvi, Alfredo ; Larocca, Luigi Maria ; Rossi, Esther; Bizzarro, Tommaso; Traini, Emanuela; Fadda, Guido.

In: PLoS One, Vol. 10, 2015, pag. e0132939-e0132939.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

AU - Martini, Maurizio

AU - Lombardi, Celestino Pio

AU - Pontecorvi, Alfredo

AU - Larocca, Luigi Maria

AU - Rossi, Esther

AU - Bizzarro, Tommaso

AU - Traini, Emanuela

AU - Fadda, Guido

PY - 2015

Y1 - 2015

N2 - Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.

AB - Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.

KW - Fine Needle Aspiration

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