The role of caveolin-1 in the regulation of angiogenesis

Alessio D'Alessio, Gigliola Sica

Risultato della ricerca: Contributo in libroContributo a convegno

Abstract

Caveolin-1 (cav-1) is the principal structural component of caveolae which functions as scaffoldiprotein for the integration of a variety of signaling pathways. In this study, we show that siRNA-induced cav-1 down regulation in human endothelial cells (EC) increased cell size and provoked cell cycle arrest at G1/S phase transition. In addition, silencing of cav-1 reduced matrix metalloproteinases (MMPs) activity which, in turn, affected cell migration and VEGF-induced tube formation of EC in vitro. These data indicate that proper expression of cav-1 is required for maintaining typical functions of EC such as proliferation and the formation of new blood vessels. In addition, we observed a marked increase of cell size, after cav-1 silencing, which might indicate the involvement of this scaffolding protein in the way by which cells perceive changes in their microenvironment. In conclusion, this study proposes cav-1 as an interesting target molecule for studying cellular mechanisms which occur in physiological as well as pathological conditions such as senescence and tumorigenesis.
Lingua originaleEnglish
Titolo della pubblicazione ospiteITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY
Pagine53
Numero di pagine1
Stato di pubblicazionePubblicato - 2012
EventoCONGRESSO NAZIONALE DELLA SOCIETA' ITALIANA DI ANATOMIA E ISTOLOGIA (SIAI) - Pistoia
Durata: 20 set 201223 set 2012

Convegno

ConvegnoCONGRESSO NAZIONALE DELLA SOCIETA' ITALIANA DI ANATOMIA E ISTOLOGIA (SIAI)
CittàPistoia
Periodo20/9/1223/9/12

Keywords

  • CAVEOLIN

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