The role of caveolin-1 in the regulation of angiogenesis

Alessio D'Alessio, Gigliola Sica

Risultato della ricerca: Contributo in libroContributo a convegno

Abstract

Caveolin-1 (cav-1) is the principal structural component of caveolae which functions as scaffolding protein for the integration of a variety of signaling pathways. In this study, we show that siRNA-induced cav-1 down regulation in human endothelial cells (EC) increased cell size and provoked cell cycle arrest at G1/S phase transition. In addition, silencing of cav-1 reduced matrix metalloproteinases (MMPs) activity which, in turn, affected cell migration and VEGF-induced tube formation of EC in vitro. These data indicate that proper expression of cav-1 is required for maintaining typical functions of EC such as proliferation and the formation of new blood vessels. In addition, we observed a marked increase of cell size, after cav-1 silencing, which might indicate the involvement of this scaffolding protein in the way by which cells perceive changes in their microenvironment. In conclusion, this study proposes cav-1 as an interesting target molecule for studying cellular mechanisms which occur in physiological as well as pathological conditions such as senescence and tumorigenesis.
Lingua originaleEnglish
Titolo della pubblicazione ospite66° Congresso Nazionale S.I.A.I. Società Italiana di Anatomia e Istologia Pistoia.
Pagine53
Numero di pagine1
Stato di pubblicazionePubblicato - 2012
Evento66° Congresso Nazionale S.I.A.I. Società Italiana di Anatomia e Istologia Pistoia. - Pistoia
Durata: 20 set 201223 set 2012

Serie di pubblicazioni

NomeITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY

Convegno

Convegno66° Congresso Nazionale S.I.A.I. Società Italiana di Anatomia e Istologia Pistoia.
CittàPistoia
Periodo20/9/1223/9/12

Keywords

  • Angiogenesis
  • Caveolin

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