TY - JOUR
T1 - The role of brachytherapy (interventional radiotherapy) for primary and/or recurrent vulvar cancer: a Gemelli Vul.Can multidisciplinary team systematic review
AU - Lancellotta, V.
AU - Macchia, Gabriella
AU - Garganese, Giorgia
AU - Fionda, B.
AU - Fragomeni, Simona Maria
AU - D'Aviero, Andrea
AU - Casà, C.
AU - Gui, Benedetta
AU - Gentileschi, Stefano
AU - Corrado, Giacomo
AU - Inzani, Frediano
AU - Rovirosa, A.
AU - Morganti, A. G.
AU - Morganti, Alessio Giuseppe
AU - Gambacorta, Maria Antonietta
AU - Tagliaferri, Luca
PY - 2021
Y1 - 2021
N2 - Objective: The aim of our systematic review was to assess the role of interventional radiotherapy (IRT, brachytherapy) in the management of primary and/or recurrent vulvar carcinoma. Evidence acquisition: A systematic research using PubMed, Scopus and Cochrane library was performed. ClinicalTrials.gov was searched for ongoing or recently completed trials, and PROSPERO was searched for ongoing or recently completed systematic reviews. Only full-text English-language articles related to IRT for treatment of primary or recurrent VC were identified and reviewed. Conference paper, survey, letter, editorial, book chapter and review were excluded. Time restriction (1990–2018) as concerns the years of the publication was considered. Evidence synthesis: Primary disease: the median 5-year LC was 43.5% (range 19–68%); the median 5-year DFS was 44.5% (range 44–81%); the median 5-year OS was 50.5% (range 27–85%). Recurrent disease: the median 5-year DFS was 64% (range 56–72%) and the median 5-year OS was 45% (range 33%-57%). Acute ≥ grade 2 toxicity was reported in three patients (1.6%). The severe late toxicity rates (grade 3–4) ranged from 0% to 14.3% (median 7.7%). Conclusion: IRT as part of primary treatment for primary and/or recurrent vulvar cancer is associated with promising clinical outcomes.
AB - Objective: The aim of our systematic review was to assess the role of interventional radiotherapy (IRT, brachytherapy) in the management of primary and/or recurrent vulvar carcinoma. Evidence acquisition: A systematic research using PubMed, Scopus and Cochrane library was performed. ClinicalTrials.gov was searched for ongoing or recently completed trials, and PROSPERO was searched for ongoing or recently completed systematic reviews. Only full-text English-language articles related to IRT for treatment of primary or recurrent VC were identified and reviewed. Conference paper, survey, letter, editorial, book chapter and review were excluded. Time restriction (1990–2018) as concerns the years of the publication was considered. Evidence synthesis: Primary disease: the median 5-year LC was 43.5% (range 19–68%); the median 5-year DFS was 44.5% (range 44–81%); the median 5-year OS was 50.5% (range 27–85%). Recurrent disease: the median 5-year DFS was 64% (range 56–72%) and the median 5-year OS was 45% (range 33%-57%). Acute ≥ grade 2 toxicity was reported in three patients (1.6%). The severe late toxicity rates (grade 3–4) ranged from 0% to 14.3% (median 7.7%). Conclusion: IRT as part of primary treatment for primary and/or recurrent vulvar cancer is associated with promising clinical outcomes.
KW - Advanced vulvar cancer
KW - Brachytherapy
KW - Interventional radiotherapy
KW - Outcomes
KW - Recurrences
KW - Toxicity
KW - Advanced vulvar cancer
KW - Brachytherapy
KW - Interventional radiotherapy
KW - Outcomes
KW - Recurrences
KW - Toxicity
UR - http://hdl.handle.net/10807/205491
U2 - 10.1007/s12094-021-02557-1
DO - 10.1007/s12094-021-02557-1
M3 - Article
SN - 1699-048X
VL - 2021
SP - 1611
EP - 1619
JO - CLINICAL & TRANSLATIONAL ONCOLOGY
JF - CLINICAL & TRANSLATIONAL ONCOLOGY
ER -