The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma

Quirino Lai; Nicoletta De Matthaeis; Michele Finotti; Giovanni Galati; Giuseppe Marrone; Fabio Melandro; Filomena Morisco; Daniele Nicolini; Riccardo Pravisani; Edoardo G. Giannini; A. Aglitti; C. Aliberti; U. Baccarani; S. Bhoori; M. Borzio; G. Brancaccio; P. Burra; G. Cabibbo; A. Casadei Gardini; P. Carrai; U. Cillo; F. Conti; A. Cucchetti; R. D’Ambrosio; C. Dell’Unto; G. G. Di Costanzo; S. Di Sandro; F. G. Foschi; F. Fucilli; M. Gambato; Antonio Gasbarrini; Felice Giuliante; D. Ghinolfi; Antonio Grieco; S. Gruttaduria; M. Guarino; A. Kostandini; M. Iavarone; I. Lenci; G. B. Levi Sandri; F. Losito; L. G. Lupo; T. M. Manzia; S. Mazzocato; C. Mescoli; Luca Miele; M. Muley; M. Persico; M. C. Plaz Torres; Maurizio Pompili; Francesca Romana Ponziani; Gian Ludovico Rapaccini; M. Rendina; M. Renzulli; Marco Rossi; E. Rreka; F. P. Russo; R. Sacco; A. Sangiovanni; A. Sessa; N. Simonetti; C. Sposito; R. Tortora; F. Trevisani; L. Viganò; M. Viganò; E. Villa; V. Vincenzi; P. Violi; A. Vitale

doi:10.1111/eci.13870

The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma

Quirino Lai, Nicoletta De Matthaeis, Michele Finotti, Giovanni Galati, Giuseppe Marrone, Fabio Melandro, Filomena Morisco, Daniele Nicolini, Riccardo Pravisani, Edoardo G. Giannini, A. Aglitti, C. Aliberti, U. Baccarani, S. Bhoori, M. Borzio, G. Brancaccio, P. Burra, G. Cabibbo, A. Casadei Gardini, P. CarraiU. Cillo, F. Conti, A. Cucchetti, R. D’Ambrosio, C. Dell’Unto, G. G. Di Costanzo, S. Di Sandro, F. G. Foschi, F. Fucilli, M. Gambato, Antonio Gasbarrini, Felice Giuliante, D. Ghinolfi, Antonio Grieco, S. Gruttaduria, M. Guarino, A. Kostandini, M. Iavarone, I. Lenci, G. B. Levi Sandri, F. Losito, L. G. Lupo, T. M. Manzia, S. Mazzocato, C. Mescoli, Luca Miele, M. Muley, M. Persico, M. C. Plaz Torres, Maurizio Pompili, Francesca Romana Ponziani, Gian Ludovico Rapaccini, M. Rendina, M. Renzulli, Marco Rossi, E. Rreka, F. P. Russo, R. Sacco, A. Sangiovanni, A. Sessa, N. Simonetti, C. Sposito, R. Tortora, F. Trevisani, L. Viganò, M. Viganò, E. Villa, V. Vincenzi, P. Violi, A. Vitale

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Aim To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment. Methods A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases. Two HCC clinical settings were explored: (i) incidence, and (ii) death after any HCC treatment. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to compare the pooled data between patients who received or did not receive APT. Results A total of 20 studies were identified, of whom 15 focused on HCC incidence, including 2,685,009 patients, and five on post-treatment death, including 3281 patients. APT was associated with an overall reduced risk of HCC incidence (OR: 0.63; 95%CI = 0.51-0.79; p < 0.001) as well as of post-treatment mortality (OR: 0.54; 95%CI = 0.35-0.83; p = 0.006). Conclusions Current data suggest that APT correlated with higher HCC incidence and poor overall survival following tumour treatment.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	European Journal of Clinical Investigation
Volume	53
DOI	https://doi.org/10.1111/eci.13870
Stato di pubblicazione	Pubblicato - 2023

Keywords

aspirin
clopidogrel
incidence
occurrence
survival

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10.1111/eci.13870

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Lai, Q., De Matthaeis, N., Finotti, M., Galati, G., Marrone, G., Melandro, F., Morisco, F., Nicolini, D., Pravisani, R., Giannini, E. G., Aglitti, A., Aliberti, C., Baccarani, U., Bhoori, S., Borzio, M., Brancaccio, G., Burra, P., Cabibbo, G., Casadei Gardini, A., ... Vitale, A. (2023). The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma. European Journal of Clinical Investigation, 53, N/A-N/A. https://doi.org/10.1111/eci.13870

@article{f9d20978d6d142c8a76695979ae962a5,

title = "The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma",

abstract = "Aim To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment. Methods A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases. Two HCC clinical settings were explored: (i) incidence, and (ii) death after any HCC treatment. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to compare the pooled data between patients who received or did not receive APT. Results A total of 20 studies were identified, of whom 15 focused on HCC incidence, including 2,685,009 patients, and five on post-treatment death, including 3281 patients. APT was associated with an overall reduced risk of HCC incidence (OR: 0.63; 95%CI = 0.51-0.79; p < 0.001) as well as of post-treatment mortality (OR: 0.54; 95%CI = 0.35-0.83; p = 0.006). Conclusions Current data suggest that APT correlated with higher HCC incidence and poor overall survival following tumour treatment.",

keywords = "aspirin, clopidogrel, incidence, occurrence, survival, aspirin, clopidogrel, incidence, occurrence, survival",

author = "Quirino Lai and {De Matthaeis}, Nicoletta and Michele Finotti and Giovanni Galati and Giuseppe Marrone and Fabio Melandro and Filomena Morisco and Daniele Nicolini and Riccardo Pravisani and Giannini, {Edoardo G.} and A. Aglitti and C. Aliberti and U. Baccarani and S. Bhoori and M. Borzio and G. Brancaccio and P. Burra and G. Cabibbo and {Casadei Gardini}, A. and P. Carrai and U. Cillo and F. Conti and A. Cucchetti and R. D{\textquoteright}Ambrosio and C. Dell{\textquoteright}Unto and {Di Costanzo}, {G. G.} and {Di Sandro}, S. and Foschi, {F. G.} and F. Fucilli and M. Gambato and Antonio Gasbarrini and Felice Giuliante and D. Ghinolfi and Antonio Grieco and S. Gruttaduria and M. Guarino and A. Kostandini and M. Iavarone and I. Lenci and {Levi Sandri}, {G. B.} and F. Losito and Lupo, {L. G.} and Manzia, {T. M.} and S. Mazzocato and C. Mescoli and Luca Miele and M. Muley and M. Persico and {Plaz Torres}, {M. C.} and Maurizio Pompili and Ponziani, {Francesca Romana} and Rapaccini, {Gian Ludovico} and M. Rendina and M. Renzulli and Marco Rossi and E. Rreka and Russo, {F. P.} and R. Sacco and A. Sangiovanni and A. Sessa and N. Simonetti and C. Sposito and R. Tortora and F. Trevisani and L. Vigan{\`o} and M. Vigan{\`o} and E. Villa and V. Vincenzi and P. Violi and A. Vitale",

year = "2023",

doi = "10.1111/eci.13870",

language = "English",

volume = "53",

pages = "N/A--N/A",

journal = "European Journal of Clinical Investigation",

issn = "0014-2972",

publisher = "Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: [email protected], INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205",

}

Lai, Q, De Matthaeis, N, Finotti, M, Galati, G, Marrone, G, Melandro, F, Morisco, F, Nicolini, D, Pravisani, R, Giannini, EG, Aglitti, A, Aliberti, C, Baccarani, U, Bhoori, S, Borzio, M, Brancaccio, G, Burra, P, Cabibbo, G, Casadei Gardini, A, Carrai, P, Cillo, U, Conti, F, Cucchetti, A, D’Ambrosio, R, Dell’Unto, C, Di Costanzo, GG, Di Sandro, S, Foschi, FG, Fucilli, F, Gambato, M, Gasbarrini, A , Giuliante, F, Ghinolfi, D, Grieco, A, Gruttaduria, S, Guarino, M, Kostandini, A, Iavarone, M, Lenci, I, Levi Sandri, GB, Losito, F, Lupo, LG, Manzia, TM, Mazzocato, S, Mescoli, C, Miele, L, Muley, M, Persico, M, Plaz Torres, MC, Pompili, M , Ponziani, FR, Rapaccini, GL, Rendina, M, Renzulli, M, Rossi, M, Rreka, E, Russo, FP, Sacco, R, Sangiovanni, A, Sessa, A, Simonetti, N, Sposito, C, Tortora, R, Trevisani, F, Viganò, L, Viganò, M, Villa, E, Vincenzi, V, Violi, P & Vitale, A 2023, 'The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma', European Journal of Clinical Investigation, vol. 53, pagg. N/A-N/A. https://doi.org/10.1111/eci.13870

TY - JOUR

T1 - The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma

AU - Lai, Quirino

AU - De Matthaeis, Nicoletta

AU - Finotti, Michele

AU - Galati, Giovanni

AU - Marrone, Giuseppe

AU - Melandro, Fabio

AU - Morisco, Filomena

AU - Nicolini, Daniele

AU - Pravisani, Riccardo

AU - Giannini, Edoardo G.

AU - Aglitti, A.

AU - Aliberti, C.

AU - Baccarani, U.

AU - Bhoori, S.

AU - Borzio, M.

AU - Brancaccio, G.

AU - Burra, P.

AU - Cabibbo, G.

AU - Casadei Gardini, A.

AU - Carrai, P.

AU - Cillo, U.

AU - Conti, F.

AU - Cucchetti, A.

AU - D’Ambrosio, R.

AU - Dell’Unto, C.

AU - Di Costanzo, G. G.

AU - Di Sandro, S.

AU - Foschi, F. G.

AU - Fucilli, F.

AU - Gambato, M.

AU - Gasbarrini, Antonio

AU - Giuliante, Felice

AU - Ghinolfi, D.

AU - Grieco, Antonio

AU - Gruttaduria, S.

AU - Guarino, M.

AU - Kostandini, A.

AU - Iavarone, M.

AU - Lenci, I.

AU - Levi Sandri, G. B.

AU - Losito, F.

AU - Lupo, L. G.

AU - Manzia, T. M.

AU - Mazzocato, S.

AU - Mescoli, C.

AU - Miele, Luca

AU - Muley, M.

AU - Persico, M.

AU - Plaz Torres, M. C.

AU - Pompili, Maurizio

AU - Ponziani, Francesca Romana

AU - Rapaccini, Gian Ludovico

AU - Rendina, M.

AU - Renzulli, M.

AU - Rossi, Marco

AU - Rreka, E.

AU - Russo, F. P.

AU - Sacco, R.

AU - Sangiovanni, A.

AU - Sessa, A.

AU - Simonetti, N.

AU - Sposito, C.

AU - Tortora, R.

AU - Trevisani, F.

AU - Viganò, L.

AU - Viganò, M.

AU - Villa, E.

AU - Vincenzi, V.

AU - Violi, P.

AU - Vitale, A.

PY - 2023

Y1 - 2023

N2 - Aim To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment. Methods A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases. Two HCC clinical settings were explored: (i) incidence, and (ii) death after any HCC treatment. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to compare the pooled data between patients who received or did not receive APT. Results A total of 20 studies were identified, of whom 15 focused on HCC incidence, including 2,685,009 patients, and five on post-treatment death, including 3281 patients. APT was associated with an overall reduced risk of HCC incidence (OR: 0.63; 95%CI = 0.51-0.79; p < 0.001) as well as of post-treatment mortality (OR: 0.54; 95%CI = 0.35-0.83; p = 0.006). Conclusions Current data suggest that APT correlated with higher HCC incidence and poor overall survival following tumour treatment.

AB - Aim To evaluate the impact of antiplatelet therapy (APT)on the incidence of hepatocellular carcinoma (HCC) and mortality following its treatment. Methods A systematic literature search was performed using PubMed and Cochrane Central Register of Controlled Trials Databases. Two HCC clinical settings were explored: (i) incidence, and (ii) death after any HCC treatment. Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to compare the pooled data between patients who received or did not receive APT. Results A total of 20 studies were identified, of whom 15 focused on HCC incidence, including 2,685,009 patients, and five on post-treatment death, including 3281 patients. APT was associated with an overall reduced risk of HCC incidence (OR: 0.63; 95%CI = 0.51-0.79; p < 0.001) as well as of post-treatment mortality (OR: 0.54; 95%CI = 0.35-0.83; p = 0.006). Conclusions Current data suggest that APT correlated with higher HCC incidence and poor overall survival following tumour treatment.

KW - aspirin

KW - clopidogrel

KW - incidence

KW - occurrence

KW - survival

KW - aspirin

KW - clopidogrel

KW - incidence

KW - occurrence

KW - survival

UR - http://hdl.handle.net/10807/244917

U2 - 10.1111/eci.13870

DO - 10.1111/eci.13870

M3 - Article

SN - 0014-2972

VL - 53

SP - N/A-N/A

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

ER -

The role of antiplatelet therapies on incidence and mortality of hepatocellular carcinoma

Abstract

Keywords

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