The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes

Bianca Rocca; Federico Santilli; Dario Pitocco; Luciana Mucci; Giovanna Petrucci; E Vitacolonna; S Lattanzio; D Mattoscio; Francesco Zaccardi; R Liani; N Vazzana; A Del Ponte; E Ferrante; Francesca Martini; Carmine Cardillo; Roberta Morosetti; Massimiliano Mirabella; Giovanni Ghirlanda; G Davì; Carlo Patrono

doi:10.1111/j.1538-7836.2012.04723.x

The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes

Bianca Rocca
, Federico Santilli
, Dario Pitocco
, Luciana Mucci
, Giovanna Petrucci
, E Vitacolonna
, S Lattanzio
, D Mattoscio
, Francesco Zaccardi
, R Liani
, N Vazzana
, A Del Ponte
, E Ferrante
, Francesca Martini
, Carmine Cardillo
, Roberta Morosetti
, Massimiliano Mirabella
, Giovanni Ghirlanda
, G Davì
, Carlo Patrono^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

174 Citazioni (Scopus)

Abstract

Interindividual variability in response to aspirin has been popularized as 'resistance'. We hypothesized that faster recovery of platelet cyclooxygenase-1 activity may explain incomplete thromboxane (TX) inhibition during the 24-h dosing interval.

Lingua originale	Inglese
pagine (da-a)	1220-1230
Numero di pagine	11
Rivista	Journal of Thrombosis and Haemostasis
Volume	10
Numero di pubblicazione	7
DOI	https://doi.org/10.1111/j.1538-7836.2012.04723.x
Stato di pubblicazione	Pubblicato - 2012

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Ematologia

Keywords

aspirin
cyclooxygenase
low-dose

Accesso al documento

10.1111/j.1538-7836.2012.04723.x

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Rocca, B., Santilli, F., Pitocco, D., Mucci, L., Petrucci, G., Vitacolonna, E., Lattanzio, S., Mattoscio, D., Zaccardi, F., Liani, R., Vazzana, N., Del Ponte, A., Ferrante, E., Martini, F., Cardillo, C., Morosetti, R., Mirabella, M., Ghirlanda, G., Davì, G., & Patrono, C. (2012). The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes. Journal of Thrombosis and Haemostasis, 10(7), 1220-1230. https://doi.org/10.1111/j.1538-7836.2012.04723.x

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title = "The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes",

abstract = "Interindividual variability in response to aspirin has been popularized as 'resistance'. We hypothesized that faster recovery of platelet cyclooxygenase-1 activity may explain incomplete thromboxane (TX) inhibition during the 24-h dosing interval.",

keywords = "aspirin, cyclooxygenase, low-dose, aspirin, cyclooxygenase, low-dose",

author = "Bianca Rocca and Federico Santilli and Dario Pitocco and Luciana Mucci and Giovanna Petrucci and E Vitacolonna and S Lattanzio and D Mattoscio and Francesco Zaccardi and R Liani and N Vazzana and \{Del Ponte\}, A and E Ferrante and Francesca Martini and Carmine Cardillo and Roberta Morosetti and Massimiliano Mirabella and Giovanni Ghirlanda and G Dav{\`i} and Carlo Patrono",

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doi = "10.1111/j.1538-7836.2012.04723.x",

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Rocca, B, Santilli, F, Pitocco, D, Mucci, L, Petrucci, G, Vitacolonna, E, Lattanzio, S, Mattoscio, D, Zaccardi, F, Liani, R, Vazzana, N, Del Ponte, A, Ferrante, E, Martini, F, Cardillo, C, Morosetti, R, Mirabella, M, Ghirlanda, G, Davì, G & Patrono, C 2012, 'The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes', Journal of Thrombosis and Haemostasis, vol. 10, n. 7, pagg. 1220-1230. https://doi.org/10.1111/j.1538-7836.2012.04723.x

TY - JOUR

T1 - The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes

AU - Rocca, Bianca

AU - Santilli, Federico

AU - Pitocco, Dario

AU - Mucci, Luciana

AU - Petrucci, Giovanna

AU - Vitacolonna, E

AU - Lattanzio, S

AU - Mattoscio, D

AU - Zaccardi, Francesco

AU - Liani, R

AU - Vazzana, N

AU - Del Ponte, A

AU - Ferrante, E

AU - Martini, Francesca

AU - Cardillo, Carmine

AU - Morosetti, Roberta

AU - Mirabella, Massimiliano

AU - Ghirlanda, Giovanni

AU - Davì, G

AU - Patrono, Carlo

PY - 2012

Y1 - 2012

N2 - Interindividual variability in response to aspirin has been popularized as 'resistance'. We hypothesized that faster recovery of platelet cyclooxygenase-1 activity may explain incomplete thromboxane (TX) inhibition during the 24-h dosing interval.

AB - Interindividual variability in response to aspirin has been popularized as 'resistance'. We hypothesized that faster recovery of platelet cyclooxygenase-1 activity may explain incomplete thromboxane (TX) inhibition during the 24-h dosing interval.

KW - aspirin

KW - cyclooxygenase

KW - low-dose

KW - aspirin

KW - cyclooxygenase

KW - low-dose

UR - https://publicatt.unicatt.it/handle/10807/40040

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U2 - 10.1111/j.1538-7836.2012.04723.x

DO - 10.1111/j.1538-7836.2012.04723.x

M3 - Article

SN - 1538-7933

VL - 10

SP - 1220

EP - 1230

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 7

ER -

The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes

Abstract

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