The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia

M Tarnani; Luca Laurenti; Pg Longo; Nicola Piccirillo; S Gobessi; A Mannocci; S Marietti; Simona Sica; G Leone; Dg Efremov

doi:10.1016/j.leukres.2009.12.020

The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia

M Tarnani, Luca Laurenti, Pg Longo, Nicola Piccirillo, S Gobessi, A Mannocci, S Marietti, Simona Sica, G Leone, Dg Efremov

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

We recently reported that leukemic cells from IgVH-unmutated/progressive CLL more frequently proliferate in response to CpG-ODN stimulation than their corresponding counterparts. Here we evaluated the prognostic impact of this proliferative response in 91 CLL patients. The proliferative response was highly predictive of PFS, TTT and OS in the whole series and refined prognosis in patients with M-CLL. BCR stimulation modulated the response to CpG-ODN, suggesting that the proliferative capacity of the leukemic cells is related to antigen-encounter history. These data support the hypothesis that the capacity of the leukemic cells to respond to external stimuli influences disease progression in CLL.

Lingua originale	English
pagine (da-a)	1189-1194
Numero di pagine	6
Rivista	Leukemia Research
Volume	34
DOI	https://doi.org/10.1016/j.leukres.2009.12.020
Stato di pubblicazione	Pubblicato - 2010

Keywords

Cell Proliferation
CpG Islands
Female
Humans
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Multivariate Analysis
Oligodeoxyribonucleotides
Survival Analysis

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10.1016/j.leukres.2009.12.020

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title = "The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia",

abstract = "We recently reported that leukemic cells from IgVH-unmutated/progressive CLL more frequently proliferate in response to CpG-ODN stimulation than their corresponding counterparts. Here we evaluated the prognostic impact of this proliferative response in 91 CLL patients. The proliferative response was highly predictive of PFS, TTT and OS in the whole series and refined prognosis in patients with M-CLL. BCR stimulation modulated the response to CpG-ODN, suggesting that the proliferative capacity of the leukemic cells is related to antigen-encounter history. These data support the hypothesis that the capacity of the leukemic cells to respond to external stimuli influences disease progression in CLL.",

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author = "M Tarnani and Luca Laurenti and Pg Longo and Nicola Piccirillo and S Gobessi and A Mannocci and S Marietti and Simona Sica and G Leone and Dg Efremov",

year = "2010",

doi = "10.1016/j.leukres.2009.12.020",

language = "English",

volume = "34",

pages = "1189--1194",

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TY - JOUR

T1 - The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia

AU - Tarnani, M

AU - Laurenti, Luca

AU - Longo, Pg

AU - Piccirillo, Nicola

AU - Gobessi, S

AU - Mannocci, A

AU - Marietti, S

AU - Sica, Simona

AU - Leone, G

AU - Efremov, Dg

PY - 2010

Y1 - 2010

N2 - We recently reported that leukemic cells from IgVH-unmutated/progressive CLL more frequently proliferate in response to CpG-ODN stimulation than their corresponding counterparts. Here we evaluated the prognostic impact of this proliferative response in 91 CLL patients. The proliferative response was highly predictive of PFS, TTT and OS in the whole series and refined prognosis in patients with M-CLL. BCR stimulation modulated the response to CpG-ODN, suggesting that the proliferative capacity of the leukemic cells is related to antigen-encounter history. These data support the hypothesis that the capacity of the leukemic cells to respond to external stimuli influences disease progression in CLL.

AB - We recently reported that leukemic cells from IgVH-unmutated/progressive CLL more frequently proliferate in response to CpG-ODN stimulation than their corresponding counterparts. Here we evaluated the prognostic impact of this proliferative response in 91 CLL patients. The proliferative response was highly predictive of PFS, TTT and OS in the whole series and refined prognosis in patients with M-CLL. BCR stimulation modulated the response to CpG-ODN, suggesting that the proliferative capacity of the leukemic cells is related to antigen-encounter history. These data support the hypothesis that the capacity of the leukemic cells to respond to external stimuli influences disease progression in CLL.

KW - Cell Proliferation

KW - CpG Islands

KW - Female

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Male

KW - Multivariate Analysis

KW - Oligodeoxyribonucleotides

KW - Survival Analysis

KW - Cell Proliferation

KW - CpG Islands

KW - Female

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Male

KW - Multivariate Analysis

KW - Oligodeoxyribonucleotides

KW - Survival Analysis

UR - http://hdl.handle.net/10807/57038

U2 - 10.1016/j.leukres.2009.12.020

DO - 10.1016/j.leukres.2009.12.020

M3 - Article

SN - 0145-2126

VL - 34

SP - 1189

EP - 1194

JO - Leukemia Research

JF - Leukemia Research

ER -

The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia

Abstract

Keywords

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