The price study: The role of conventional and diffusion-weighted magnetic resonance imaging in assessment of locally advanced cervical cancer patients administered by chemoradiation followed by radical surgery

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Objectives To analyse the role of DW-MRI in early prediction of pathologically-assessed residual disease in locally-advanced cervical cancer (LACC) treated with neoadjuvant chemoradiotherapy followed by radical surgery. Methods Between October 2010–June 2014, 108 women with histologically-proven cervical cancer were screened; 88 were included in this study. Tumour volume (TV) and ADC mean were measured before (baseline-MRI) and after 2 weeks of chemoradiotherapy (early-MRI). According to histopathology, treatment response was classified as complete (CR) or partial (PR). Comparisons were made with Mann-Whitney, Wilcoxon and χ2 tests. ROC curves were generated for statistically significant parameters on univariate analysis. Results CR and PR were documented in 40 and 48 patients. At baseline-MRI, TV did not differ between groups. At early-MRI, TV was higher in PR than in CR (p=0.001). ΔTV reduction after treatment was lower in PR than in CR (63.6% vs. 81.1%; p=0.001). At baseline-MRI and early-MRI, ADC mean did not differ between PR and CR. ROC curve showed best cut-off for predicting pathological PR was ΔTV reduction of 73% with sensitivity, specificity, accuracy, NPV, PPV of 73%, 72.5%, 72.7%, 76%, 69%. Conclusions TV evaluated before and early after treatment could predict pathological response in LACC. ADC mean did not correlate with treatment outcome.
Lingua originaleEnglish
pagine (da-a)2425-2435
Numero di pagine11
RivistaEuropean Radiology
Volume28
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Adult
  • Aged
  • Chemoradiotherapy
  • Combined Modality Therapy
  • Diffusion Magnetic Resonance Imaging
  • Diffusionmagneticresonance imaging
  • Female
  • Humans
  • Hysterectomy
  • Magnetic Resonance Imaging
  • Magnetic resonance imaging
  • Middle Aged
  • Neoadjuvant Therapy
  • Neoplasm Staging
  • Postoperative Care
  • Prospective Studies
  • ROC Curve
  • Tumor Burden
  • Tumour volume
  • Uterine Cervical Neoplasms
  • Uterine cervical neoplasms

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