The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review

M. Monticelli; P. Zeppa; F. Zenga; R. Altieri; M. Mammi; L. Bertero; I. Castellano; P. Cassoni; A. Melcarne; Giuseppe La Rocca; Giovanni Sabatino; A. Ducati; D. Garbossa

doi:10.1016/j.clineuro.2018.05.015

The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review

M. Monticelli, P. Zeppa, F. Zenga, R. Altieri, M. Mammi, L. Bertero, I. Castellano, P. Cassoni, A. Melcarne, Giuseppe La Rocca, Giovanni Sabatino, A. Ducati, D. Garbossa

University of Turin

Risultato della ricerca: Contributo in rivista › Articolo in rivista

12 Citazioni (Scopus)

Abstract

Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior.The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment.

Lingua originale	English
pagine (da-a)	120-126
Numero di pagine	7
Rivista	Clinical Neurology and Neurosurgery
Volume	170
DOI	https://doi.org/10.1016/j.clineuro.2018.05.015
Stato di pubblicazione	Pubblicato - 2018

Keywords

BRAE
Glioblastoma
High grade gliomas
IDH1
IDH2
MGMT
Molecular biology
TERT

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10.1016/j.clineuro.2018.05.015

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Monticelli, M., Zeppa, P., Zenga, F., Altieri, R., Mammi, M., Bertero, L., Castellano, I., Cassoni, P., Melcarne, A., La Rocca, G., Sabatino, G., Ducati, A., & Garbossa, D. (2018). The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review. Clinical Neurology and Neurosurgery, 170, 120-126. https://doi.org/10.1016/j.clineuro.2018.05.015

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title = "The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review",

abstract = "Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior.The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment.",

keywords = "BRAE, Glioblastoma, High grade gliomas, IDH1, IDH2, MGMT, Molecular biology, TERT, BRAE, Glioblastoma, High grade gliomas, IDH1, IDH2, MGMT, Molecular biology, TERT",

author = "M. Monticelli and P. Zeppa and F. Zenga and R. Altieri and M. Mammi and L. Bertero and I. Castellano and P. Cassoni and A. Melcarne and {La Rocca}, Giuseppe and Giovanni Sabatino and A. Ducati and D. Garbossa",

year = "2018",

doi = "10.1016/j.clineuro.2018.05.015",

language = "English",

volume = "170",

pages = "120--126",

journal = "Clinical Neurology and Neurosurgery",

issn = "0303-8467",

publisher = "Elsevier B.V.",

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Monticelli, M, Zeppa, P, Zenga, F, Altieri, R, Mammi, M, Bertero, L, Castellano, I, Cassoni, P, Melcarne, A, La Rocca, G, Sabatino, G, Ducati, A & Garbossa, D 2018, 'The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review', Clinical Neurology and Neurosurgery, vol. 170, pagg. 120-126. https://doi.org/10.1016/j.clineuro.2018.05.015

TY - JOUR

T1 - The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review

AU - Monticelli, M.

AU - Zeppa, P.

AU - Zenga, F.

AU - Altieri, R.

AU - Mammi, M.

AU - Bertero, L.

AU - Castellano, I.

AU - Cassoni, P.

AU - Melcarne, A.

AU - La Rocca, Giuseppe

AU - Sabatino, Giovanni

AU - Ducati, A.

AU - Garbossa, D.

PY - 2018

Y1 - 2018

N2 - Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior.The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment.

AB - Glioblastoma (GBM) is the most common glioma in adults, with incidence increasing by 3% per year. According to the World Health Organization Classification of Central Nervous System Tumors, GBM is considered a grade IV tumor due to its malignant behavior.The aim of this review is to summarize the main biological aspects of GBM. In particular, we focused our attention on those alterations which have been proven to have an impact on patients' outcome, mainly in terms of overall survival (OS), or on the tumor response to therapies. We have also analyzed the cellular biology and the interactions between GBM and the surrounding environment.

KW - BRAE

KW - Glioblastoma

KW - High grade gliomas

KW - IDH1

KW - IDH2

KW - MGMT

KW - Molecular biology

KW - TERT

KW - BRAE

KW - Glioblastoma

KW - High grade gliomas

KW - IDH1

KW - IDH2

KW - MGMT

KW - Molecular biology

KW - TERT

UR - http://hdl.handle.net/10807/172248

U2 - 10.1016/j.clineuro.2018.05.015

DO - 10.1016/j.clineuro.2018.05.015

M3 - Article

SN - 0303-8467

VL - 170

SP - 120

EP - 126

JO - Clinical Neurology and Neurosurgery

JF - Clinical Neurology and Neurosurgery

ER -

The post-surgical era of GBM: How molecular biology has impacted on our clinical management. A review

Abstract

Keywords

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