The pharmacological management of patients with comorbid psoriasis and obesity

Andrea Chiricozzi, Paolo Gisondi, Giampiero Girolomoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

Introduction: Psoriasis is a chronic inflammatory skin disease that is increasingly being recognized as a complex disorder affecting multiple systems. Systemic inflammation is considered the pathogenic link between psoriasis and its comorbid conditions that include arthritis, metabolic disorders, depression, and cardiovascular diseases. The presence of comorbid conditions modifies both its clinical management and the therapeutic approach in psoriatic patients. Areas covered: This review describes the clinical, epidemiological, and pathogenic link between psoriasis and obesity. Furthermore, data related to the effects of synthetic antipsoriatic drugs on obesity are collated. Expert opinion: Obesity is one of the most common comorbid conditions that is relevant both for a patient’s overall health and the clinical outcomes of antipsoriatic therapies. Indeed, some treatments of psoriasis might be impaired by adiposity. Moreover, obesity’s association with dyslipidemia, hypertension, and increased liver enzymes could further be worsened by acitretin, cyclosporine and methotrexate, respectively. Therefore, the identification of therapeutic targets whose blockade could have positive effects on both psoriasis and mechanisms regulating body weight homeostasis may be of great relevance to the treatment of patients with psoriasis.
Lingua originaleEnglish
pagine (da-a)863-872
Numero di pagine10
RivistaEXPERT OPINION ON PHARMACOTHERAPY
Volume20
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Adipokines
  • Antibodies, Monoclonal
  • Cytokines
  • Dermatologic Agents
  • Humans
  • IL-17
  • Immunosuppressive Agents
  • Methotrexate
  • Obesity
  • Phototherapy
  • Psoriasis
  • adipokines
  • guselkumab
  • leptin
  • obesity
  • resistin

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